MolNFT v2 · #129380 · protein

Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917

5O6H: “Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917”. X-ray diffraction at 1.29, 4 ligands (MYA, 9M2, MG). MolNFT v2 #129380 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5O6H
Type: protein
Length: 764 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.29
Source: Homo sapiens
UniProt: P30419
Ligands: MYA, 9M2, MG, PO4

Structure

x-ray diffraction · resolution 1.29 · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	—	protein	382	—	P30419

Ligands and binding sites

MYA · Tetradecanoyl-coa · ligand · 2 copies · chains A, B
9M2 · 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B
PO4 · Phosphate ion · ion · 8 copies · chains A, B
GOL · Glycerol · additive · 3 copies · chains A, B
DMS · Dimethyl sulfoxide · additive

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5O6H · Human NMT1 in complex with myristoyl-CoA and inhibitor imp-917 · the same entry in another collection · chain A against A, TM-score 1.00
P30419 · AlphaFold monomer V2.0 prediction for glycylpeptide N-tetradecanoyltransferase 1 (P30419) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30419
Elsewhere: RCSB PDB 5O6H · PDBe 5O6H · UniProt P30419

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