UniProt P30419
Glycylpeptide N-tetradecanoyltransferase 1 (P30419)
Glycylpeptide N-tetradecanoyltransferase 1 (UniProt P30419), EC 2.3.1.97: 48 experimental structures on GenesisL1, 16 ligands bound, 41 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P30419
- Protein
- Glycylpeptide N-tetradecanoyltransferase 1
- EC
- 2.3.1.97
- Experimental structures
- 48
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 41 · 7 records with a druggable one
Structures
48 records of P30419 in the MolNFT archive: 48 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RXT | Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase. | x-ray diffraction | A, B, C, D | — | — |
| 1RXT | Crystal structure of human myristoyl-COA:PROTEIN N- myristoyltransferase. | x-ray diffraction | A, B, C, D | — | — |
| 3IU1 | Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA | x-ray diffraction | A, B | — | — |
| 3IU1 | Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA | x-ray diffraction | A, B | — | — |
| 3IU2 | Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor… | x-ray diffraction | A, B | — | — |
| 3IU2 | Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor… | x-ray diffraction | A, B | — | — |
| 3IWE | Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor… | x-ray diffraction | A, B | — | — |
| 3IWE | Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor… | x-ray diffraction | A, B | — | — |
| 3JTK | Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor… | x-ray diffraction | A, B | — | — |
| 3JTK | Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor… | x-ray diffraction | A, B | — | — |
| 4C2Y | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA co-factor | x-ray diffraction | A, B | — | — |
| 4C2Y | Human N-myristoyltransferase (NMT1) with myristoyl-CoA co-factor | x-ray diffraction | A, B | — | — |
| 4C2Z | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound | x-ray diffraction | A, B | — | — |
| 4C2Z | Human N-myristoyltransferase (NMT1) with myristoyl-CoA and inhibitor bound | x-ray diffraction | A, B | — | — |
| 5MU6 | Human N-myristoyltransferase (NMT1) with myristoyl-CoA and imp-1088 inhibitor bound | x-ray diffraction | A, B | MYA, MG, KFK | — |
| 5NPQ | Human N-myristoyltransferase 1 (MNT1) with Myristoyl-CoA analogue X10 bound | x-ray diffraction | A, B | 94Q, MG | — |
| 5NPQ | Human N-myristoyltransferase 1 (MNT1) with myristoyl-CoA analogue X10 bound | x-ray diffraction | A, B | 94Q, MG | — |
| 5O6H | Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917 | x-ray diffraction | A, B | MYA, PO4, 9M2, MG | — |
| 5O6H | Human NMT1 in complex with myristoyl-CoA and inhibitor imp-917 | x-ray diffraction | A, B | MYA, PO4, 9M2, MG | — |
| 5O6J | Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-1031 | x-ray diffraction | A, B | MYA, PO4, MG, 9M8 | 5 (best 0.81) |
| 5O6J | Human NMT1 in complex with myristoyl-CoA and inhibitor imp-1031 | x-ray diffraction | A, B | MYA, PO4, MG, 9M8 | — |
| 5O9S | HSNMT1 in complex with CoA and myristoylated-gksnsklk octapeptide | x-ray diffraction | A, B | CL, MYR | — |
| 5O9T | HSNMT1 in complex with CoA and acetylated-ncfskpk peptide | x-ray diffraction | A, B | MYA, CL | — |
| 5O9U | HSNMT1 in complex with CoA and myristoylated-gcsvskkk octapeptide | x-ray diffraction | A, B | COA, MYR | — |
| 5O9V | HSNMT1 in complex with CoA and myristoylated-ggcfskpk octapeptide | x-ray diffraction | A, B | COA, CL, MYR | — |
| 5UUT | N-myristoyltransferase 1 (nmt) bound to myristoyl-CoA | x-ray diffraction | A, B | MYA | — |
| 6EHJ | Human N-myristoyltransferase (NMT1) with myristoyl-CoA and peptide bound | x-ray diffraction | A, B | MYA, MYR, COA | — |
| 6F56 | Mutant of Human N-myristoyltransferase with bound myristoyl-CoA | x-ray diffraction | A, B, C, D | MYA, MG | — |
| 6F56 | Mutant of human N-myristoyltransferase with bound myristoyl-CoA | x-ray diffraction | A, B, C, D | MYA, MG | — |
| 6FZ2 | Human N-myristoyltransferase (NMT1) with myristoyl-CoA and inhibitor bound | x-ray diffraction | A, B | 31A, MYA, MG | — |
| 6FZ3 | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound | x-ray diffraction | A, B | EBK, MYA, MG | 5 (best 0.78) |
| 6FZ3 | Human N-myristoyltransferase (NMT1) with myristoyl-CoA and inhibitor bound | x-ray diffraction | A, B | EBK, MYA, MG | — |
| 6FZ5 | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound | x-ray diffraction | A, B | BXN, MYA, MG | 5 (best 0.78) |
| 6FZ5 | Human N-myristoyltransferase (NMT1) with myristoyl-CoA and inhibitor bound | x-ray diffraction | A, B | BXN, MYA, MG | — |
| 6PAV | Structure of Human NMT1 with products CoA and myristoyl-lysine peptide with acetylated N-terminus | x-ray diffraction | B, A | COA, MYR | — |
| 6PAV | Structure of human NMT1 with products CoA and myristoyl-lysine peptide with acetylated N-terminus | x-ray diffraction | B, A | ACE, COA, MYR | — |
| 6QRM | HSNMT1 in complex with both myrcoa and gncfskrraa substrates | x-ray diffraction | A, B | COA, CL, MYA, MYR | — |
| 6SJZ | HSNMT1 in complex with both myrcoa and acetylated-gncfskpr substrates | x-ray diffraction | A, B | ACE, MYA, CL | — |
| 6SK2 | HsNMT1 in complex with both MyrCoA and Acetylated-GKSFSKPR peptide reveals N-terminal Lysine… | x-ray diffraction | A, B | COA, MYA, MYR | 8 (best 0.78) |
| 6SK2 | HSNMT1 in complex with both myrcoa and acetylated-gksfskpr peptide reveals N-terminal lysine… | x-ray diffraction | A, B | ACE, COA, MYA, MYR | — |
| 6SK3 | C-terminal HSNMT1 DELTAC3 truncation in complex with both myrcoa and gncfskpr substrates | x-ray diffraction | A, B | MYA, MG | — |
| 6SK8 | DELTAC3 C-terminal truncation of HSNMT1 in complex with myrcoa and gdcfskpr substrates | x-ray diffraction | A, B | MYA, CL | — |
| 6SKJ | DELTAC2 C-terminal truncation of HSNMT1 in complex with myrcoa and gncfskpr substrates | x-ray diffraction | A, B | COA, MG, MYA, MYR | — |
| 7RK3 | Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated… | x-ray diffraction | A | 4PS, MYR, 6NA | — |
| 8Q26 | HsNMT1 in complex with both MyrCoA and GNCFSKPR inhibitor peptide | x-ray diffraction | A, B | COA, CL, MG, MYR | 6 (best 0.76) |
| 8Q2Z | HsNMT1 in complex with both MyrCoA and GNLLSKFR peptide | x-ray diffraction | A, B | COA, CL, MG, MYR | 6 (best 0.77) |
| 8Q3T | HsNMT1 in complex with both MyrCoA and GNCFSKPRVPTK inhibitor peptide | x-ray diffraction | A, B | COA, CL, MYR | 6 (best 0.77) |
| P30419 | AlphaFold monomer V2.0 prediction for glycylpeptide N-tetradecanoyltransferase 1 (P30419) | — | — | — |
Ligands
- MYA · Tetradecanoyl-coa · in 22 records
- MG · Magnesium ion · in 18 records
- MYR · Myristic acid · in 14 records
- COA · Coenzyme A · in 12 records
- CL · Chloride ion · in 9 records
- PO4 · Phosphate ion · in 4 records
- ACE · Acetyl group · in 3 records
- 94Q · ~{S}-[2-[3-[[(2~{S})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 9-(3-but-3-ynyl-1,2-diazirin-3-yl)nonanethioate · in 2 records
- 9M2 · 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine · in 2 records
- 9M8 · 1-[5-[3-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl) ethoxy]phenyl]-1-methyl-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine · in 2 records
- BXN · 4-[3-[(8~{A}~{R})-3,4,6,7,8,8~{A}-hexahydro-1~{H}-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-bis(chloranyl)-~{N}-methyl-~{N}-(1,3,5-trimethylpyrazol-4-yl) benzenesulfonamide · in 2 records
- EBK · 2,6-bis(chloranyl)-4-[2-(4-methylpiperazin-1-yl) pyridin-4-yl]-~{N}-(1,3,5-trimethylpyrazol-4-yl) benzenesulfonamide · in 2 records
- 31A · N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide · in 1 record
- 4PS · 4'-diphospho pantetheine · in 1 record
- 6NA · Hexanoic acid · in 1 record
- KFK · 1-[5-[3,4-bis(fluoranyl)-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-1-methyl-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine · in 1 record
Elsewhere
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