MolNFT v2 · #118457 · protein
Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate
5ETJ: “Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with…”. X-ray diffraction at 2.3, 2 ligands (IM5, PO4). MolNFT v2 #118457 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ETJ
- Type
- protein
- Length
- 1,727 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.3
- Source
- Homo sapiens
- UniProt
- P00491
- Ligands
- IM5, PO4
Structure
x-ray diffraction · resolution 2.3 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, E, F | — | protein | 288 | — | P00491 |
| B | — | protein | 287 | — | P00491 |
Ligands and binding sites
- IM5 · 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one · ligand · 6 copies · chains A, B, C, D, F, E
- PO4 · Phosphate ion · ion · 12 copies · chains A, C, B, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5ETJ · Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human… · the same entry in another collection · chain F against F, TM-score 1.00
- P00491 · AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase (P00491) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00491
- Elsewhere: RCSB PDB 5ETJ · PDBe 5ETJ · UniProt P00491
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