MolNFT v1 · #303925 · protein
AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase (P00491)
P00491: “AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase (P00491)”. 2 pockets (best druggability 0.67). MolNFT v1 #303925 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P00491
- Type
- protein
- Length
- 289 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7c75F0f7d6d136A2b8D4C6C6e9b3D8a697949DF1
- Molecule
- Purine nucleoside phosphorylase
- UniProt
- P00491
- Pockets
- 2 · best druggability 0.67
Structure
1 distinct chain · 34% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Purine nucleoside phosphorylase | protein | 289 | 34% helix, 23% strand | P00491 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.67 | 0.88 | 24 | empty |
| 2 | 170 | 0.54 | 0.80 | 25 | empty |
Compared structures
- 5ETJ · Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human… · an experimental structure of the same protein · chain A against A, TM-score 0.98
- 4EAR · Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant… · an experimental structure of the same protein · chain A against B, TM-score 0.98
- 3K8O · Crystal structure of human purine nucleoside phosphorylase in complex with datme-immh · an experimental structure of the same protein · chain A against U, TM-score 0.97
- 3K8O · Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH · an experimental structure of the same protein · chain A against U, TM-score 0.97
- 3PHB · Crystal structure of human purine nucleoside phosphorylase in complex with dadme-immg · an experimental structure of the same protein · chain A against U, TM-score 0.97
- 3PHB · Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG · an experimental structure of the same protein · chain A against U, TM-score 0.97
- 5UGF · Crystal structure of human purine nucleoside phosphorylase (F159Y) mutant complexed with… · an experimental structure of the same protein · chain A against E, TM-score 0.97
- 4EB8 · Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant… · an experimental structure of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00491
- Elsewhere: UniProt P00491 · AlphaFold DB P00491
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