UniProt P00491
Purine nucleoside phosphorylase (P00491)
Purine nucleoside phosphorylase (UniProt P00491), EC 2.4.2.1: 77 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 56 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P00491
- Protein
- Purine nucleoside phosphorylase
- EC
- 2.4.2.1
- Experimental structures
- 77
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 56 · 7 records with a druggable one
Structures
78 records of P00491 in the MolNFT archive: 77 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1M73 | Crystal structure of human pnp at 2.3A resolution | x-ray diffraction | E | — | — |
| 1M73 | Crystal structure of human pnp at 2.3A resolution | x-ray diffraction | E | — | — |
| 1PF7 | Crystal structure of human pnp complexed with immucillin H | x-ray diffraction | E | — | — |
| 1PF7 | Crystal structure of human pnp complexed with immucillin H | x-ray diffraction | E | — | — |
| 1PWY | Crystal structure of human pnp complexed with acyclovir | x-ray diffraction | E | — | — |
| 1PWY | Crystal structure of human pnp complexed with acyclovir | x-ray diffraction | E | — | — |
| 1RCT | Crystal structure of Human purine nucleoside phosphorylase complexed with INOSINE | x-ray diffraction | E | — | — |
| 1RCT | Crystal structure of human purine nucleoside phosphorylase complexed with inosine | x-ray diffraction | E | — | — |
| 1RFG | Crystal Structure of Human Purine Nucleoside Phosphorylase Complexed with Guanosine | x-ray diffraction | E | — | — |
| 1RFG | Crystal structure of human purine nucleoside phosphorylase complexed with guanosine | x-ray diffraction | E | — | — |
| 1RR6 | Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and phosphate | x-ray diffraction | A | — | — |
| 1RR6 | Structure of human purine nucleoside phosphorylase in complex with immucillin-H and phosphate | x-ray diffraction | A | — | — |
| 1RSZ | Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate | x-ray diffraction | A | — | — |
| 1RSZ | Structure of human purine nucleoside phosphorylase in complex with dadme-immucillin-H and sulfate | x-ray diffraction | A | — | — |
| 1RT9 | Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and sulfate | x-ray diffraction | A | — | — |
| 1RT9 | Structure of human purine nucleoside phosphorylase in complex with immucillin-H and sulfate | x-ray diffraction | A | — | — |
| 1ULA | Application of crystallographic and modeling methods in the design of purine nucleoside… | x-ray diffraction | A | — | — |
| 1ULA | Application of crystallographic and modeling methods in the design of purine nucleoside… | x-ray diffraction | A | — | — |
| 1ULB | Application of crystallographic and modeling methods in the design of purine nucleoside… | x-ray diffraction | A | — | — |
| 1ULB | Application of crystallographic and modeling methods in the design of purine nucleoside… | x-ray diffraction | A | — | — |
| 1V2H | Crystal structure of human PNP complexed with guanine | x-ray diffraction | E | — | — |
| 1V2H | Crystal structure of human pnp complexed with guanine | x-ray diffraction | E | — | — |
| 1V3Q | Structure of human PNP complexed with DDI | x-ray diffraction | E | — | — |
| 1V3Q | Structure of human pnp complexed with ddi | x-ray diffraction | E | — | — |
| 1V41 | Crystal structure of human PNP complexed with 8-Azaguanine | x-ray diffraction | E | — | — |
| 1V41 | Crystal structure of human pnp complexed with 8-azaguanine | x-ray diffraction | E | — | — |
| 1V45 | Crystal Structure of human PNP complexed with 3-deoxyguanosine | x-ray diffraction | E | — | — |
| 1V45 | Crystal structure of human pnp complexed with 3-deoxyguanosine | x-ray diffraction | E | — | — |
| 1YRY | Crystal structure of human PNP complexed with MESG | x-ray diffraction | E | — | — |
| 1YRY | Crystal structure of human pnp complexed with mesg | x-ray diffraction | E | — | — |
| 2A0W | Structure of human purine nucleoside phosphorylase H257G mutant | x-ray diffraction | A | — | — |
| 2A0W | Structure of human purine nucleoside phosphorylase H257G mutant | x-ray diffraction | A | — | — |
| 2A0X | Structure of human purine nucleoside phosphorylase H257F mutant | x-ray diffraction | A | — | — |
| 2A0X | Structure of human purine nucleoside phosphorylase H257F mutant | x-ray diffraction | A | — | — |
| 2A0Y | Structure of human purine nucleoside phosphorylase H257D mutant | x-ray diffraction | A | — | — |
| 2A0Y | Structure of human purine nucleoside phosphorylase H257D mutant | x-ray diffraction | A | — | — |
| 2OC4 | Crystal structure of human purine nucleoside phosphorylase mutant H257D with Imm-H | x-ray diffraction | A | — | — |
| 2OC4 | Crystal structure of human purine nucleoside phosphorylase mutant H257D with imm-H | x-ray diffraction | A | — | — |
| 2OC9 | Crystal structure of human purine nucleoside phosphorylase mutant H257G with Imm-H | x-ray diffraction | A | — | — |
| 2OC9 | Crystal structure of human purine nucleoside phosphorylase mutant H257G with imm-H | x-ray diffraction | A | — | — |
| 2ON6 | Crystal structure of human purine nucleoside phosphorylase mutant H257F with Imm-H | x-ray diffraction | A | — | — |
| 2ON6 | Crystal structure of human purine nucleoside phosphorylase mutant H257F with imm-H | x-ray diffraction | A | — | — |
| 2Q7O | Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H | x-ray diffraction | E | — | — |
| 2Q7O | Structure of human purine nucleoside phosphorylase in complex with L- immucillin-H | x-ray diffraction | E | — | — |
| 3BGS | Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate | x-ray diffraction | A | — | — |
| 3BGS | Structure of human purine nucleoside phosphorylase with L-dadme-immh and phosphate | x-ray diffraction | A | — | — |
| 3D1V | Crystal structure of human PNP complexed with 2-mercapto(3H) quinazoli | x-ray diffraction | A | — | — |
| 3D1V | Crystal structure of human pnp complexed with 2-MERCAPTO(3H) quinazolinone | x-ray diffraction | A | — | — |
| 3GB9 | Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoroadenine | x-ray diffraction | A, B, C | — | — |
| 3GB9 | Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoroadenine | x-ray diffraction | A, B, C | — | — |
| 3GGS | Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with… | x-ray diffraction | A, B, C | — | — |
| 3GGS | Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with… | x-ray diffraction | A, B, C | — | — |
| 3INY | Crystal structure of human purine nucleoside phosphorylase in complex with 7-deazaguanine | x-ray diffraction | A | — | — |
| 3INY | Crystal structure of human purine nucleoside phosphorylase in complex with 7-deazaguanine | x-ray diffraction | A | — | — |
| 3K8O | Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH | x-ray diffraction | E, Q, S, T, U, Y | — | — |
| 3K8O | Crystal structure of human purine nucleoside phosphorylase in complex with datme-immh | x-ray diffraction | E, Q, S, T, U, Y | — | — |
| 3K8Q | Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H | x-ray diffraction | A | — | — |
| 3K8Q | Crystal structure of human purine nucleoside phosphorylase in complex with serme-immucillin H | x-ray diffraction | A | — | — |
| 3PHB | Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG | x-ray diffraction | E, Q, S, T, U, Y | — | — |
| 3PHB | Crystal structure of human purine nucleoside phosphorylase in complex with dadme-immg | x-ray diffraction | E, Q, S, T, U, Y | — | — |
18 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 4 records
- IM5 · 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one · in 3 records
- PO4 · Phosphate ion · in 3 records
- NA · Sodium ion · in 2 records
- TEW · 6-tungstotellurate(VI) · in 2 records
- CL · Chloride ion · in 1 record
- JSI · [(~{E})-2-[5-bromanyl-2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenyl]ethenyl]phosphonic acid · in 1 record
- JT3 · [(~{E})-2-[2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]-6-[2,3,4,5,6-pentakis(fluoranyl)phenoxy]phenyl]ethenyl]phosphonic acid · in 1 record
- JTC · [(~{E})-2-[2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]-5-[2,3,4,5,6-pentakis(fluoranyl)phenoxy]phenyl]ethenyl]phosphonic acid · in 1 record
- JTO · [2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenoxy]methylphosphonic acid · in 1 record
- JU9 · [(~{E})-2-[4-methoxy-2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenyl]ethenyl]phosphonic acid · in 1 record
Experiment against prediction
- 4EB8 chain C against the predicted model P00491: TM-score 0.99, RMSD 0.59 Å
- 3K8O chain T against the predicted model P00491: TM-score 0.99, RMSD 0.61 Å
- 3K8O chain T against the predicted model P00491: TM-score 0.99, RMSD 0.61 Å
- 3K8O chain S against the predicted model P00491: TM-score 0.99, RMSD 0.63 Å
- 3K8O chain S against the predicted model P00491: TM-score 0.99, RMSD 0.63 Å
- 3K8O chain E against the predicted model P00491: TM-score 0.99, RMSD 0.66 Å
- 3K8O chain E against the predicted model P00491: TM-score 0.99, RMSD 0.66 Å
- 4GKA chain D against the predicted model P00491: TM-score 0.99, RMSD 0.67 Å
- 7ZSL chain D against the predicted model P00491: TM-score 0.99, RMSD 0.66 Å
- 3K8O chain U against the predicted model P00491: TM-score 0.99, RMSD 0.75 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.