MolNFT v1 · #98479 · protein
Crystal structure of a therapeutic single chain antibody in the free form
4LAQ · Single chain antibody fragment SCFV6H4: “Crystal structure of a therapeutic single chain antibody in the free form”. X-ray diffraction, 3 ligands (MLT, NI, SO4), 2 pockets (best druggability 0.59). MolNFT v1 #98479 on GenesisL1: 3D…
- PDB
- 4LAQ
- Type
- protein
- Length
- 222 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Single chain antibody fragment SCFV6H4
- Ligands
- MLT, NI, SO4
- Pockets
- 2 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 1% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Single chain antibody fragment SCFV6H4 | protein | 222 | 1% helix, 50% strand | — |
Ligands and binding sites
- MLT · D-malate · ligand · chains H
- NI · Nickel (II) ion · metal · chains H
- SO4 · Sulfate ion · ion · chains H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.59 | 0.85 | 17 | empty |
| 2 | 55 | 0.33 | 0.77 | 16 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4LAQ · Crystal structure of a therapeutic single chain antibody in the free form · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4LAQ · PDBe 4LAQ
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