MolNFT v1 · #9796 · protein
Crystal structure of human mitotic-specific ubiquitin-conjugating enzyme, UBCH10
1I7K · Ubiquitin-conjugating enzyme E2 H10: “Crystal structure of human mitotic-specific ubiquitin-conjugating enzyme, UBCH10”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #9796 on GenesisL1: 3D structure, binding sites…
- PDB
- 1I7K
- Type
- protein
- Length
- 292 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2 H10
- EC
- 6.3.2.19
- UniProt
- O00762
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ubiquitin-conjugating enzyme E2 H10 (EC 6.3.2.19) | protein | 146 | 34% helix, 22% strand | O00762 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.35 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 522 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1I7K · Crystal structure of human mitotic-specific ubiquitin-conjugating enzyme, UBCH10 · the same entry in another collection · chain A against A, TM-score 1.00
- O00762 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 C (O00762) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00762
- Elsewhere: RCSB PDB 1I7K · PDBe 1I7K · UniProt O00762
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