UniProt O00762
Ubiquitin-conjugating enzyme E2 C (O00762)
Ubiquitin-conjugating enzyme E2 C (UniProt O00762), EC 2.3.2.23, 2.3.2.24: 10 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00762
- Protein
- Ubiquitin-conjugating enzyme E2 C
- EC
- 2.3.2.23, 2.3.2.24, 6.3.2.19
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 3 · 2 records with a druggable one
Structures
11 records of O00762 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1I7K | Crystal structure of human mitotic-specific ubiquitin-conjugating enzyme, UBCH10 | x-ray diffraction | A, B | — | 1 (best 0.35) |
| 1I7K | Crystal structure of human mitotic-specific ubiquitin-conjugating enzyme, UBCH10 | x-ray diffraction | A, B | — | — |
| 4YII | Structure of an APC2-UBCH10 complex reveals distinctive cullin-RING ligase mechanism for… | x-ray diffraction | U | — | — |
| 4YII | Structure of an APC2-UBCH10 complex reveals distinctive cullin-ring ligase mechanism for… | x-ray diffraction | U | — | — |
| 5KHR | Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with… | electron microscopy | Q | — | — |
| 5KHR | Model of human anaphase-promoting COMPLEX/CYCLOSOME complex (APC15 deletion mutant) in complex with… | electron microscopy | Q | — | — |
| 5L9U | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin… | electron microscopy | U | — | — |
| 5L9U | Model of human anaphase-promoting COMPLEX/CYCLOSOME (APC/C-CDH1) with a cross linked ubiquitin… | electron microscopy | U | — | — |
| 8TAR | APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD | electron microscopy | Q | — | 1 (best 0.67) |
| 8TAU | APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB | electron microscopy | Q | — | 1 (best 0.68) |
| O00762 | AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 C (O00762) | predicted | A | — | — |
Experiment against prediction
- 5KHR chain Q against the predicted model O00762: TM-score 1.00, RMSD 0.30 Å
- 5KHR chain Q against the predicted model O00762: TM-score 1.00, RMSD 0.30 Å
- 4YII chain U against the predicted model O00762: TM-score 1.00, RMSD 0.30 Å
- 4YII chain U against the predicted model O00762: TM-score 1.00, RMSD 0.30 Å
- 5L9U chain U against the predicted model O00762: TM-score 1.00, RMSD 0.30 Å
- 5L9U chain U against the predicted model O00762: TM-score 1.00, RMSD 0.30 Å
- 8TAU chain Q against the predicted model O00762: TM-score 0.98, RMSD 0.60 Å
- 1I7K chain A against the predicted model O00762: TM-score 0.98, RMSD 0.61 Å
- 1I7K chain A against the predicted model O00762: TM-score 0.98, RMSD 0.61 Å
- 8TAR chain Q against the predicted model O00762: TM-score 0.98, RMSD 0.69 Å
Elsewhere
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