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Crystal structure of human mitotic-specific ubiquitin-conjugating enzyme, UBCH10

Analyse Crystal structure of human mitotic-specific ubiquitin-conjugating enzyme, UBCH10 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1I7K
Type: protein
Length: 292 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-conjugating enzyme E2 H10
EC: 6.3.2.19
UniProt: O00762
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ubiquitin-conjugating enzyme E2 H10 (EC 6.3.2.19)	protein	146	34% helix, 22% strand	O00762

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.35	0.76	24	empty

Interfaces

1 interface between chains.

A–B · 522 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

1I7K · Crystal structure of human mitotic-specific ubiquitin-conjugating enzyme, UBCH10 · the same entry in another collection · chain A against A, TM-score 1.00
O00762 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 C (O00762) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00762
Elsewhere: RCSB PDB 1I7K · PDBe 1I7K · UniProt O00762

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