MolNFT v1 · #97369 · protein

Crystal structure of the human mortalin (GRP75) ATPase domain in the apo form

4KBO · Stress-70 protein, mitochondrial: “Crystal structure of the human mortalin (GRP75) ATPase domain in the apo form”. X-ray diffraction, 1 ligand (NA), 3 pockets (best druggability 0.71). MolNFT v1 #97369 on GenesisL1: 3D structure…

PDB: 4KBO
Type: protein
Length: 374 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Stress-70 protein, mitochondrial
UniProt: P38646
Ligands: NA
Pockets: 3 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Stress-70 protein, mitochondrial	protein	374	40% helix, 28% strand	P38646

Ligands and binding sites

NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	390	0.71	0.82	52	NA
2	211	0.58	0.80	32	empty
3	56	0.31	0.76	17	empty

Compared structures

4KBO · Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form · the same entry in another collection · chain A against A, TM-score 1.00
P38646 · AlphaFold monomer V2.0 prediction for stress-70 protein, mitochondrial (P38646) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38646
Elsewhere: RCSB PDB 4KBO · PDBe 4KBO · UniProt P38646

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