UniProt P38646
Stress-70 protein, mitochondrial (P38646)
Stress-70 protein, mitochondrial (UniProt P38646): 9 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P38646
- Protein
- Stress-70 protein, mitochondrial
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 9 · 2 records with a druggable one
Structures
10 records of P38646 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3N8E | Substrate binding domain of the human Heat Shock 70kDa protein 9 (mortalin) | x-ray diffraction | A, B | — | — |
| 3N8E | Substrate binding domain of the human heat shock 70KDA protein 9 (mortalin) | x-ray diffraction | A, B | — | — |
| 4KBO | Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form | x-ray diffraction | A | — | — |
| 4KBO | Crystal structure of the human mortalin (GRP75) ATPase domain in the apo form | x-ray diffraction | A | — | — |
| 6NHK | Mortalin nucleotide binding domain in the ADP-bound state | x-ray diffraction | A, B | ADP, PO4, MG | 8 (best 0.77) |
| 6NHK | Mortalin nucleotide binding domain in the ADP-bound state | x-ray diffraction | A, B | ADP, PO4, MG | — |
| 6P2U | Structure of mortalin-nbd with N6-propargyladenosine-5'-diphosphate | x-ray diffraction | A | NO7, PO4, MG | — |
| 6PMT | Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate | x-ray diffraction | A | AMP, PIS, PO4 | 1 (best 0.75) |
| 6PMT | Structure of mortalin-nbd with adenosine-5'-monophosphate and thiodiphosphate | x-ray diffraction | A | AMP, PIS, PO4 | — |
| P38646 | AlphaFold monomer V2.0 prediction for stress-70 protein, mitochondrial (P38646) | predicted | A | — | — |
Ligands
- PO4 · Phosphate ion · in 5 records
- MG · Magnesium ion · in 3 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- AMP · Adenosine monophosphate · in 2 records
- PIS · Trihydrogen thiodiphosphate · in 2 records
- NO7 · 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine · in 1 record
Experiment against prediction
- 6P2U chain A against the predicted model P38646: TM-score 0.89, RMSD 2.57 Å
- 4KBO chain A against the predicted model P38646: TM-score 0.89, RMSD 2.58 Å
- 4KBO chain A against the predicted model P38646: TM-score 0.89, RMSD 2.58 Å
- 6NHK chain A against the predicted model P38646: TM-score 0.88, RMSD 2.60 Å
- 6NHK chain A against the predicted model P38646: TM-score 0.88, RMSD 2.60 Å
- 6PMT chain A against the predicted model P38646: TM-score 0.88, RMSD 2.57 Å
- 6PMT chain A against the predicted model P38646: TM-score 0.88, RMSD 2.57 Å
- 6NHK chain B against the predicted model P38646: TM-score 0.88, RMSD 2.59 Å
- 6NHK chain B against the predicted model P38646: TM-score 0.88, RMSD 2.59 Å
- 3N8E chain A against the predicted model P38646: TM-score 0.69, RMSD 1.20 Å
Elsewhere
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