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Crystal structure of the human mortalin (GRP75) ATPase domain in the apo form

Analyse Crystal structure of the human mortalin (GRP75) ATPase domain in the apo form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4KBO
Type: protein
Length: 374 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Stress-70 protein, mitochondrial
UniProt: P38646
Ligands: NA
Pockets: 3 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Stress-70 protein, mitochondrial	protein	374	40% helix, 28% strand	P38646

Ligands and binding sites

NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	390	0.71	0.82	52	NA
2	211	0.58	0.80	32	empty
3	56	0.31	0.76	17	empty

Compared structures

4KBO · Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form · the same entry in another collection · chain A against A, TM-score 1.00
P38646 · AlphaFold monomer V2.0 prediction for stress-70 protein, mitochondrial (P38646) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38646
Elsewhere: RCSB PDB 4KBO · PDBe 4KBO · UniProt P38646

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