MolNFT v1 · #96328 · protein
Structure of the SOCS2-elongin bc complex bound to an N-terminal fragment of CULLIN5
4JGH · Suppressor of cytokine signaling 2: “Structure of the SOCS2-elongin bc complex bound to an N-terminal fragment of CULLIN5”. X-ray diffraction, 6 pockets (best druggability 0.63). MolNFT v1 #96328 on GenesisL1: 3D structure, binding…
- PDB
- 4JGH
- Type
- protein
- Length
- 731 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Suppressor of cytokine signaling 2; Transcription elongation factor B polypeptide 2…
- UniProt
- O14508, P62869, P83940, Q93034
- Pockets
- 6 · best druggability 0.63
Structure
x-ray diffraction · 4 distinct chains · 54% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor of cytokine signaling 2 | protein | 163 | 34% helix, 19% strand | O14508 |
| B | Transcription elongation factor B polypeptide 2 | protein | 104 | 17% helix, 32% strand | P62869 |
| C | Transcription elongation factor B polypeptide 1 | protein | 96 | 41% helix, 15% strand | P83940 |
| D | Cullin-5 | protein | 368 | 76% helix, 0% strand | Q93034 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.63 | 0.80 | 32 | empty |
| 2 | 201 | 0.61 | 0.82 | 25 | empty |
| 3 | 161 | 0.50 | 0.77 | 20 | empty |
| 4 | 212 | 0.49 | 0.76 | 23 | empty |
| 5 | 68 | 0.47 | 0.83 | 16 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1199 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 1004 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 829 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 237 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 192 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4JGH · Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5 · the same entry in another collection · chain D against D, TM-score 1.00
- P62869 · AlphaFold monomer V2.0 prediction for elongin-B (P62869) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q93034 · AlphaFold monomer V2.0 prediction for cullin-5 (Q93034) · a predicted model of the same protein · chain D against A, TM-score 0.97
- P83940 · AlphaFold monomer V2.0 prediction for elongin-C (P83940) · a predicted model of the same protein · chain C against A, TM-score 0.88
- O14508 · AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 2 (O14508) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14508
- Every structure of UniProt P62869
- Every structure of UniProt P83940
- Every structure of UniProt Q93034
- Elsewhere: RCSB PDB 4JGH · PDBe 4JGH · UniProt O14508 · UniProt P62869 · UniProt P83940 · UniProt Q93034
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