MolNFT v1 · #959 · protein
Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN-and FAD-containing enzymes
1AMO: “Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN-and FAD-containing enzymes”. X-ray diffraction, 3 ligands (FAD, FMN, NAP), 12 pockets (best druggability 0.77). MolNFT v1 #959 on GenesisL1: 3D…
- PDB
- 1AMO
- Type
- protein
- Length
- 1,202 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NADPH-cytochrome P450 reductase
- EC
- 1.6.2.4
- UniProt
- P00388
- Ligands
- FAD, FMN, NAP
- Pockets
- 12 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | NADPH-cytochrome P450 reductase (EC 1.6.2.4) | protein | 601 | 37% helix, 20% strand | P00388 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 513 | 0.77 | 0.84 | 64 | FAD, FMN |
| 2 | 414 | 0.76 | 0.86 | 59 | empty |
| 3 | 493 | 0.76 | 0.84 | 60 | FAD, FMN |
| 4 | 974 | 0.76 | 0.79 | 73 | empty |
| 5 | 349 | 0.72 | 0.84 | 35 | NAP |
Interfaces
1 interface between chains.
- A–B · 703 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1AMO · Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN-and… · the same entry in another collection · chain A against A, TM-score 1.00
- P00388 · AlphaFold monomer V2.0 prediction for NADPH--cytochrome P450 reductase (P00388) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00388
- Elsewhere: RCSB PDB 1AMO · PDBe 1AMO · UniProt P00388
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