MolNFT v1 · #9405 · protein
Structural and electrophysiological analysis of annexin V mutants. mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter
1HVE: “Structural and electrophysiological analysis of annexin V mutants. mutagenesis of human annexin V, an in…”. X-ray diffraction, 2 ligands (CA, SO4), 4 pockets (best druggability 0.58). MolNFT v1 #9405 on GenesisL1: 3D structure…
- PDB
- 1HVE
- Type
- protein
- Length
- 312 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Annexin V
- UniProt
- P08758
- Ligands
- CA, SO4
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Annexin V | protein | 312 | 71% helix, 0% strand | P08758 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.58 | 0.83 | 16 | empty |
| 2 | 86 | 0.54 | 0.85 | 21 | empty |
| 3 | 106 | 0.51 | 0.82 | 23 | empty |
| 4 | 74 | 0.35 | 0.75 | 14 | empty |
Compared structures
- 1HVE · Structural and electrophysiological analysis of annexin V mutants. mutagenesis of human… · the same entry in another collection · chain A against A, TM-score 1.00
- P08758 · AlphaFold monomer V2.0 prediction for annexin A5 (P08758) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08758
- Elsewhere: RCSB PDB 1HVE · PDBe 1HVE · UniProt P08758
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