MolNFT v1 · #92164 · protein
Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2- methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-IMIDAZO[1,2- B]PYRIDAZIN-8-yl)-amine
4FZ6 · Tyrosine-protein kinase syk: “Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2…”. X-ray diffraction, 1 ligand (0VG), 2 pockets (best druggability 0.60). MolNFT v1 #92164 on GenesisL1: 3D structure, binding sites…
- PDB
- 4FZ6
- Type
- protein
- Length
- 266 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase syk
- EC
- 2.7.10.2
- UniProt
- P43405
- Ligands
- 0VG
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 266 | 43% helix, 21% strand | P43405 |
Ligands and binding sites
- 0VG · N-{6-[(2S)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-b]pyridazin-8-amine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 331 | 0.60 | 0.77 | 31 | 0VG |
| 2 | 55 | 0.29 | 0.75 | 16 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43405
- Elsewhere: RCSB PDB 4FZ6 · PDBe 4FZ6 · UniProt P43405
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