MolNFT v1 · #92092 · protein + RNA
Complex structure of viral RNA polymerase form III
4FWT · Elongation factor ts, elongation factor tu, linker, Q beta…: “Complex structure of viral RNA polymerase form III”. X-ray diffraction, 2 ligands (GTP, CA), 14 pockets (best druggability 0.79). MolNFT v1 #92092 on GenesisL1: 3D…
- PDB
- 4FWT
- Type
- protein + RNA
- Length
- 1,215 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor ts, elongation factor tu, linker, Q beta replicase; RNA…
- UniProt
- P0A6P3, P0A6N3, Q8LTE0
- Ligands
- GTP, CA
- Pockets
- 14 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 35% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongation factor ts, elongation factor tu, linker, Q beta replicase | protein | 1203 | 35% helix, 21% strand | P0A6P3, P0A6N3, Q8LTE0 |
| G | RNA (5'-R(*C*CP*CP*UP*AP*CP*CP*C)-3') | rna | 6 | — | — |
| T | RNA (5'-R(*GP*GP*GP*UP*AP*GP*GP*G)-3') | rna | 6 | — | — |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A, G, T
- CA · Calcium ion · metal · 2 copies · chains A, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 727 | 0.79 | 0.84 | 77 | GTP, CA |
| 2 | 970 | 0.74 | 0.78 | 112 | empty |
| 3 | 156 | 0.61 | 0.84 | 29 | empty |
| 4 | 200 | 0.60 | 0.81 | 25 | empty |
| 5 | 313 | 0.56 | 0.76 | 36 | empty |
Interfaces
3 interfaces between chains.
- A–G · 664 Ų buried · 8 hydrogen bonds · protein-nucleic
- A–T · 528 Ų buried · 6 hydrogen bonds · protein-nucleic
- G–T · 332 Ų buried · 29 hydrogen bonds · nucleic-nucleic
Compared structures
- 4FWT · Complex structure of viral RNA polymerase form III · the same entry in another collection · chain A against A, TM-score 1.00
- P0A6P3 · AlphaFold monomer V2.0 prediction for elongation factor ts (P0A6P3) · a predicted model of the same protein · chain A against A, TM-score 0.20
- P0A6N3 · AlphaFold monomer V2.0 prediction for elongation factor tu (P0A6N3) · a predicted model of the same protein · chain A against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6P3
- Every structure of UniProt P0A6N3
- Every structure of UniProt Q8LTE0
- Elsewhere: RCSB PDB 4FWT · PDBe 4FWT · UniProt P0A6P3 · UniProt P0A6N3 · UniProt Q8LTE0
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