MolNFT v1 · #91698 · protein
Structural and biophysical characterization of the syk activation switch
4FL3 · Tyrosine-protein kinase syk: “Structural and biophysical characterization of the syk activation switch”. X-ray diffraction, 2 ligands (ANP, MG), 9 pockets (best druggability 0.63). MolNFT v1 #91698 on GenesisL1: 3D structure…
- PDB
- 4FL3
- Type
- protein
- Length
- 538 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase syk
- EC
- 2.7.10.2
- UniProt
- P43405
- Ligands
- ANP, MG
- Pockets
- 9 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 538 | 36% helix, 20% strand | P43405 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 277 | 0.63 | 0.81 | 43 | empty |
| 2 | 272 | 0.62 | 0.80 | 34 | ANP, MG |
| 3 | 166 | 0.47 | 0.77 | 25 | empty |
| 4 | 159 | 0.45 | 0.75 | 24 | empty |
| 5 | 99 | 0.40 | 0.77 | 22 | empty |
Compared structures
- 4FL3 · Structural and Biophysical Characterization of the Syk Activation Switch · the same entry in another collection · chain A against A, TM-score 1.00
- P43405 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase syk (P43405) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43405
- Elsewhere: RCSB PDB 4FL3 · PDBe 4FL3 · UniProt P43405
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.