MolNFT v1 · #9160 · protein
Crystal structure of human class mu glutathione transferase GSTM2-2: effects of lattice packing on conformational heterogeneity
1HNA · Glutathione S-transferase: “Crystal structure of human class mu glutathione transferase GSTM2-2: effects of lattice packing on…”. X-ray diffraction, 1 ligand (GDN), 1 pocket (best druggability 0.37). MolNFT v1 #9160 on GenesisL1: 3D…
- PDB
- 1HNA
- Type
- protein
- Length
- 217 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione S-transferase
- EC
- 2.5.1.18
- UniProt
- P28161
- Ligands
- GDN
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutathione S-transferase (EC 2.5.1.18) | protein | 217 | 53% helix, 10% strand | P28161 |
Ligands and binding sites
- GDN · Glutathione S-(2,4 dinitrobenzene) · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.37 | 0.74 | 16 | GDN |
Compared structures
- 1HNA · Crystal structure of human class mu glutathione transferase GSTM2-2: effects of lattice… · the same entry in another collection · chain A against A, TM-score 1.00
- P28161 · AlphaFold monomer V2.0 prediction for glutathione S-transferase mu 2 (P28161) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28161
- Elsewhere: RCSB PDB 1HNA · PDBe 1HNA · UniProt P28161
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