MolNFT v1 · #91586 · protein

NUP37-NUP120 full-length complex from schizosaccharomyces pombe

4FHN · Nucleoporin NUP37: “NUP37-NUP120 full-length complex from schizosaccharomyces pombe”. X-ray diffraction, 20 pockets (best druggability 0.86). MolNFT v1 #91586 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4FHN
Type: protein
Length: 3,128 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin NUP37; Nucleoporin NUP120; Glutamate dehydrogenase
UniProt: O36030, O43044, Q8XDW9
Pockets: 20 · best druggability 0.86

Structure

x-ray diffraction · 5 distinct chains · 36% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NUP37	protein	343	3% helix, 55% strand	O36030
B	Nucleoporin NUP120	protein	1022	44% helix, 16% strand	O43044
C	Nucleoporin NUP37	protein	344	3% helix, 55% strand	O36030
D	Nucleoporin NUP120	protein	977	44% helix, 17% strand	O43044
X	Glutamate dehydrogenase	protein	442	50% helix, 16% strand	Q8XDW9

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	898	0.86	0.88	106	empty
2	954	0.85	0.86	78	empty
3	1180	0.84	0.85	86	empty
4	684	0.83	0.86	70	empty
5	713	0.83	0.86	76	empty

Interfaces

4 interfaces between chains.

C–D · 2860 Å² buried · 43 hydrogen bonds · protein-protein
A–B · 2330 Å² buried · 26 hydrogen bonds · protein-protein
B–D · 979 Å² buried · 10 hydrogen bonds · protein-protein
B–X · 438 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4FHN · Nup37-Nup120 full-length complex from Schizosaccharomyces pombe · the same entry in another collection · chain X against X, TM-score 1.00
O36030 · AlphaFold monomer V2.0 prediction for uncharacterized wd repeat- containing protein… · a predicted model of the same protein · chain A against A, TM-score 0.95
O43044 · AlphaFold monomer V2.0 prediction for nucleoporin NUP120 (O43044) · a predicted model of the same protein · chain D against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O36030
Every structure of UniProt O43044
Every structure of UniProt Q8XDW9
Elsewhere: RCSB PDB 4FHN · PDBe 4FHN · UniProt O36030 · UniProt O43044 · UniProt Q8XDW9

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