Research workbench
NUP37-NUP120 full-length complex from schizosaccharomyces pombe
Analyse NUP37-NUP120 full-length complex from schizosaccharomyces pombe in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4FHN
- Type
- protein
- Length
- 3,128 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP37; Nucleoporin NUP120; Glutamate dehydrogenase
- UniProt
- O36030, O43044, Q8XDW9
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 5 distinct chains · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP37 | protein | 343 | 3% helix, 55% strand | O36030 |
| B | Nucleoporin NUP120 | protein | 1022 | 44% helix, 16% strand | O43044 |
| C | Nucleoporin NUP37 | protein | 344 | 3% helix, 55% strand | O36030 |
| D | Nucleoporin NUP120 | protein | 977 | 44% helix, 17% strand | O43044 |
| X | Glutamate dehydrogenase | protein | 442 | 50% helix, 16% strand | Q8XDW9 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 898 | 0.86 | 0.88 | 106 | empty |
| 2 | 954 | 0.85 | 0.86 | 78 | empty |
| 3 | 1180 | 0.84 | 0.85 | 86 | empty |
| 4 | 684 | 0.83 | 0.86 | 70 | empty |
| 5 | 713 | 0.83 | 0.86 | 76 | empty |
Interfaces
4 interfaces between chains.
- C–D · 2860 Ų buried · 43 hydrogen bonds · protein-protein
- A–B · 2330 Ų buried · 26 hydrogen bonds · protein-protein
- B–D · 979 Ų buried · 10 hydrogen bonds · protein-protein
- B–X · 438 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4FHN · Nup37-Nup120 full-length complex from Schizosaccharomyces pombe · the same entry in another collection · chain X against X, TM-score 1.00
- O36030 · AlphaFold monomer V2.0 prediction for uncharacterized wd repeat- containing protein… · a predicted model of the same protein · chain A against A, TM-score 0.95
- O43044 · AlphaFold monomer V2.0 prediction for nucleoporin NUP120 (O43044) · a predicted model of the same protein · chain D against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O36030
- Every structure of UniProt O43044
- Every structure of UniProt Q8XDW9
- Elsewhere: RCSB PDB 4FHN · PDBe 4FHN · UniProt O36030 · UniProt O43044 · UniProt Q8XDW9
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