MolNFT v1 · #91486 · protein
Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (sky)
4FEQ · Tyrosine-protein kinase receptor TYRO3: “Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (sky)”. X-ray diffraction, 1 ligand (0T8), 1 pocket (best druggability 0.64). MolNFT v1 #91486 on…
- PDB
- 4FEQ
- Type
- protein
- Length
- 224 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase receptor TYRO3
- EC
- 2.7.10.1
- UniProt
- P55144
- Ligands
- 0T8
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) | protein | 224 | 42% helix, 17% strand | P55144 |
Ligands and binding sites
- 0T8 · 4-(cyclopentylamino)-N-[3-(2-oxopyrrolidin-1-yl)propyl]-2-{[2-(pyridin-4-yl)ethyl]amino}pyrimidine-5-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.64 | 0.81 | 32 | 0T8 |
Compared structures
- 4FEQ · Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase… · the same entry in another collection · chain A against A, TM-score 1.00
- P55144 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase receptor TYRO3 (P55144) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55144
- Elsewhere: RCSB PDB 4FEQ · PDBe 4FEQ · UniProt P55144
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