UniProt P55144
Tyrosine-protein kinase receptor TYRO3 (P55144)
Tyrosine-protein kinase receptor TYRO3 (UniProt P55144), EC 2.7.10.1: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P55144
- Protein
- Tyrosine-protein kinase receptor TYRO3
- EC
- 2.7.10.1
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 5 records with a druggable one
Structures
7 records of P55144 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3QUP | Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky) | x-ray diffraction | A | LUN | 1 (best 0.63) |
| 3QUP | Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (sky) | x-ray diffraction | A | LUN | 1 (best 0.63) |
| 4FEQ | Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky) | x-ray diffraction | A | 0T8 | 1 (best 0.64) |
| 4FEQ | Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (sky) | x-ray diffraction | A | 0T8 | 1 (best 0.64) |
| 4FF8 | Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky) | x-ray diffraction | A | 14S | 1 (best 0.45) |
| 4FF8 | Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (sky) | x-ray diffraction | A | 14S | 1 (best 0.45) |
| P55144 | AlphaFold monomer V2.0 prediction for tyrosine-protein kinase receptor TYRO3 (P55144) | predicted | A | — | 4 (best 0.76) |
Ligands
- 0T8 · 4-(cyclopentylamino)-N-[3-(2-oxopyrrolidin-1-yl)propyl]-2-{[2-(pyridin-4-yl)ethyl]amino}pyrimidine-5-carboxamide · in 2 records
- 14S · 4-(cyclopentylamino)-2-[(2-methoxybenzyl)amino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide · in 2 records
- LUN · (5-fluoro-1H-indol-2-yl)[(3R)-1'-[(3R)-piperidin-3-yl]spiro[indole-3,3'-pyrrolidin]-1(2H)-yl]methanone · in 2 records
Experiment against prediction
- 4FF8 chain A against the predicted model P55144: TM-score 0.99, RMSD 0.56 Å
- 4FF8 chain A against the predicted model P55144: TM-score 0.99, RMSD 0.56 Å
- 3QUP chain A against the predicted model P55144: TM-score 0.93, RMSD 1.67 Å
- 3QUP chain A against the predicted model P55144: TM-score 0.93, RMSD 1.67 Å
- 4FEQ chain A against the predicted model P55144: TM-score 0.92, RMSD 1.77 Å
- 4FEQ chain A against the predicted model P55144: TM-score 0.92, RMSD 1.77 Å
Elsewhere
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