Research workbench
Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (sky)
Analyse Inhibitor bound structure of the kinase domain of the murine receptor tyrosine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4FEQ
- Type
- protein
- Length
- 224 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase receptor TYRO3
- EC
- 2.7.10.1
- UniProt
- P55144
- Ligands
- 0T8
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) | protein | 224 | 42% helix, 17% strand | P55144 |
Ligands and binding sites
- 0T8 · 4-(cyclopentylamino)-N-[3-(2-oxopyrrolidin-1-yl)propyl]-2-{[2-(pyridin-4-yl)ethyl]amino}pyrimidine-5-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.64 | 0.81 | 32 | 0T8 |
Compared structures
- 4FEQ · Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase… · the same entry in another collection · chain A against A, TM-score 1.00
- P55144 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase receptor TYRO3 (P55144) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55144
- Elsewhere: RCSB PDB 4FEQ · PDBe 4FEQ · UniProt P55144
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