MolNFT v1 · #91441 · protein
Crystal structure of kap BETA2-py-nls
4FDD · Transportin-1: “Crystal structure of kap BETA2-py-nls”. X-ray diffraction, 7 pockets (best druggability 0.56). MolNFT v1 #91441 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4FDD
- Type
- protein
- Length
- 856 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; RNA-binding protein fus
- UniProt
- Q92973, P35637
- Pockets
- 7 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 836 | 78% helix, 0% strand | Q92973 |
| B | RNA-binding protein fus | protein | 20 | 40% helix, 0% strand | P35637 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.56 | 0.87 | 21 | empty |
| 2 | 151 | 0.55 | 0.81 | 19 | empty |
| 3 | 111 | 0.54 | 0.83 | 18 | empty |
| 4 | 143 | 0.41 | 0.74 | 23 | empty |
| 5 | 107 | 0.37 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1329 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 4FDD · Crystal structure of KAP beta2-PY-NLS · the same entry in another collection · chain A against A, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P35637 · AlphaFold monomer V2.0 prediction for RNA-binding protein fus (P35637) · a predicted model of the same protein · chain B against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt P35637
- Elsewhere: RCSB PDB 4FDD · PDBe 4FDD · UniProt Q92973 · UniProt P35637
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