MolNFT v1 · #90879 · protein
X-ray structure of WDR5-SETD1A win motif peptide binary complex
4EWR · Wd repeat-containing protein 5: “X-ray structure of WDR5-SETD1A win motif peptide binary complex”. X-ray diffraction, 1 pocket (best druggability 0.74). MolNFT v1 #90879 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4EWR
- Type
- protein
- Length
- 314 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 5; Histone-lysine N-methyltransferase SETD1A
- EC
- 2.1.1.43
- UniProt
- P61964, O15047
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd repeat-containing protein 5 | protein | 304 | 0% helix, 52% strand | P61964 |
| C | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.43) | protein | 10 | 40% helix, 0% strand | O15047 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 497 | 0.74 | 0.83 | 44 | empty |
Interfaces
1 interface between chains.
- A–C · 613 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4EWR · X-ray structure of WDR5-SETd1a Win motif peptide binary complex · the same entry in another collection · chain A against A, TM-score 1.00
- O15047 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD1A (O15047) · a predicted model of the same protein · chain C against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Every structure of UniProt O15047
- Elsewhere: RCSB PDB 4EWR · PDBe 4EWR · UniProt P61964 · UniProt O15047
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