UniProt O15047
Histone-lysine N-methyltransferase SETD1A (O15047)
Histone-lysine N-methyltransferase SETD1A (UniProt O15047): 6 experimental structures and 1 predicted model on GenesisL1, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15047
- Protein
- Histone-lysine N-methyltransferase SETD1A
- Experimental structures
- 6
- Predicted models
- 1
- Pockets
- 8 · 1 record with a druggable one
Structures
7 records of O15047 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3S8S | Crystal structure of the RRM domain of human SETD1A | x-ray diffraction | A | — | — |
| 3S8S | Crystal structure of the rrm domain of human SETD1A | x-ray diffraction | A | — | — |
| 3UVN | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A | x-ray diffraction | B, D | — | — |
| 3UVN | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A | x-ray diffraction | B, D | — | — |
| 4EWR | X-ray structure of WDR5-SETd1a Win motif peptide binary complex | x-ray diffraction | C | — | — |
| 4EWR | X-ray structure of WDR5-SETD1A win motif peptide binary complex | x-ray diffraction | C | — | — |
| O15047 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD1A (O15047) | predicted | A | — | 8 (best 0.65) |
Experiment against prediction
- 3S8S chain A against the predicted model O15047: TM-score 0.96, RMSD 0.74 Å
- 3S8S chain A against the predicted model O15047: TM-score 0.96, RMSD 0.74 Å
- 3UVN chain D against the predicted model O15047: TM-score 0.71, RMSD 0.11 Å
- 3UVN chain D against the predicted model O15047: TM-score 0.71, RMSD 0.11 Å
- 3UVN chain B against the predicted model O15047: TM-score 0.55, RMSD 1.89 Å
- 3UVN chain B against the predicted model O15047: TM-score 0.55, RMSD 1.89 Å
- 4EWR chain C against the predicted model O15047: TM-score 0.53, RMSD 0.74 Å
- 4EWR chain C against the predicted model O15047: TM-score 0.53, RMSD 0.74 Å
Elsewhere
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