MolNFT v1 · #90595 · protein
Structure of human ceruloplasmin at 2.6 a resolution
4ENZ: “Structure of human ceruloplasmin at 2.6 a resolution”. X-ray diffraction, 6 ligands (NAG, CU, CA), 14 pockets (best druggability 0.85). MolNFT v1 #90595 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4ENZ
- Type
- protein
- Length
- 1,029 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ceruloplasmin
- EC
- 1.16.3.1
- UniProt
- P00450
- Ligands
- NAG, CU, CA, NA, O, OXY
- Pockets
- 14 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 14% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ceruloplasmin (EC 1.16.3.1) | protein | 1029 | 14% helix, 39% strand | P00450 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- CU · Copper (II) ion · metal · 6 copies · chains A
- CA · Calcium ion · metal · chains A
- NA · Sodium ion · metal · chains A
- O · Oxygen atom · ion · chains A
- OXY · Oxygen molecule · ion · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 629 | 0.85 | 0.90 | 61 | GOL |
| 2 | 602 | 0.69 | 0.78 | 89 | empty |
| 3 | 338 | 0.62 | 0.79 | 49 | empty |
| 4 | 239 | 0.62 | 0.81 | 30 | empty |
| 5 | 129 | 0.53 | 0.81 | 20 | empty |
Modifications
Observed in the structure: 5 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00450
- Elsewhere: RCSB PDB 4ENZ · PDBe 4ENZ · UniProt P00450
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