MolNFT v1 · #90413 · protein
Crystal structure of the human fyn SH3 domain in complex with the synthetic peptide VSL12
4EIK · Tyrosine-protein kinase fyn: “Crystal structure of the human fyn SH3 domain in complex with the synthetic peptide VSL12”. X-ray diffraction, 1 ligand (NA). MolNFT v1 #90413 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4EIK
- Type
- protein
- Length
- 69 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase fyn; VSL12 peptide
- EC
- 2.7.10.2
- UniProt
- P06241
- Ligands
- NA
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase fyn (EC 2.7.10.2) | protein | 58 | 5% helix, 47% strand | P06241 |
| B | VSL12 peptide | protein | 11 | 27% helix, 0% strand | — |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 612 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4EIK · Crystal Structure of the Human Fyn SH3 domain in complex with the synthetic peptide VSL12 · the same entry in another collection · chain A against A, TM-score 1.00
- P06241 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase fyn (P06241) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06241
- Elsewhere: RCSB PDB 4EIK · PDBe 4EIK · UniProt P06241
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