Research workbench
Crystal structure of the human fyn SH3 domain in complex with the synthetic peptide VSL12
Analyse Crystal structure of the human fyn SH3 domain in complex with the synthetic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EIK
- Type
- protein
- Length
- 69 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase fyn; VSL12 peptide
- EC
- 2.7.10.2
- UniProt
- P06241
- Ligands
- NA
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase fyn (EC 2.7.10.2) | protein | 58 | 5% helix, 47% strand | P06241 |
| B | VSL12 peptide | protein | 11 | 27% helix, 0% strand | — |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 612 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4EIK · Crystal Structure of the Human Fyn SH3 domain in complex with the synthetic peptide VSL12 · the same entry in another collection · chain A against A, TM-score 1.00
- P06241 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase fyn (P06241) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06241
- Elsewhere: RCSB PDB 4EIK · PDBe 4EIK · UniProt P06241
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