MolNFT v1 · #89380 · protein

Crystal structure of a C2 domain of a protein kinase C alpha (prkca) from homo sapiens at 1.90 a resolution

4DNL · Protein kinase C alpha type: “Crystal structure of a C2 domain of a protein kinase C alpha (prkca) from homo sapiens at 1.90 a resolution”. X-ray diffraction, 1 ligand (NA), 1 pocket (best druggability 0.31). MolNFT v1 #89380 on…

PDB: 4DNL
Type: protein
Length: 137 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein kinase C alpha type
EC: 2.7.11.13
UniProt: P17252
Ligands: NA
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein kinase C alpha type (EC 2.7.11.13)	protein	137	10% helix, 46% strand	P17252

Ligands and binding sites

NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.31	0.76	12	empty

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

4DNL · Crystal structure of a C2 domain of a protein kinase C alpha (PRKCA) from Homo sapiens at… · the same entry in another collection · chain A against A, TM-score 1.00
P17252 · AlphaFold monomer V2.0 prediction for protein kinase C alpha type (P17252) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17252
Elsewhere: RCSB PDB 4DNL · PDBe 4DNL · UniProt P17252

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