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Crystal structure of a C2 domain of a protein kinase C alpha (prkca) from homo sapiens at 1.90 a resolution
Analyse Crystal structure of a C2 domain of a protein kinase C alpha (prkca) from homo… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DNL
- Type
- protein
- Length
- 137 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase C alpha type
- EC
- 2.7.11.13
- UniProt
- P17252
- Ligands
- NA
- Pockets
- 1 · best druggability 0.31
Structure
x-ray diffraction · 1 distinct chain · 10% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase C alpha type (EC 2.7.11.13) | protein | 137 | 10% helix, 46% strand | P17252 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.31 | 0.76 | 12 | empty |
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 4DNL · Crystal structure of a C2 domain of a protein kinase C alpha (PRKCA) from Homo sapiens at… · the same entry in another collection · chain A against A, TM-score 1.00
- P17252 · AlphaFold monomer V2.0 prediction for protein kinase C alpha type (P17252) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17252
- Elsewhere: RCSB PDB 4DNL · PDBe 4DNL · UniProt P17252
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