UniProt P17252
Protein kinase C alpha type (P17252)
Protein kinase C alpha type (UniProt P17252), EC 2.7.11.13: 7 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P17252
- Protein
- Protein kinase C alpha type
- EC
- 2.7.11.13
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 4 · 1 record with a druggable one
Structures
8 records of P17252 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ELI | Solution structure of the second Phorbol esters/diacylglycerol binding domain of human Protein… | solution nmr | A | — | — |
| 2ELI | Solution structure of the second phorbol ESTERS/DIACYLGLYCEROL binding domain of human protein… | solution nmr | A | — | — |
| 3IW4 | Crystal structure of PKC alpha in complex with NVP-AEB071 | x-ray diffraction | A, B, C | — | — |
| 3IW4 | Crystal structure of PKC alpha in complex with nvp-AEB071 | x-ray diffraction | A, B, C | — | — |
| 4DNL | Crystal structure of a C2 domain of a protein kinase C alpha (PRKCA) from Homo sapiens at 1.90 A… | x-ray diffraction | A | — | — |
| 4DNL | Crystal structure of a C2 domain of a protein kinase C alpha (prkca) from homo sapiens at 1.90 a… | x-ray diffraction | A | — | — |
| 8U37 | Crystal structure of the catalytic domain of human PKC alpha (D463N, V568I, S657E) in complex with… | x-ray diffraction | A | V5U, MG | 4 (best 0.61) |
| P17252 | AlphaFold monomer V2.0 prediction for protein kinase C alpha type (P17252) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4DNL chain A against the predicted model P17252: TM-score 0.98, RMSD 0.71 Å
- 4DNL chain A against the predicted model P17252: TM-score 0.98, RMSD 0.71 Å
- 8U37 chain A against the predicted model P17252: TM-score 0.98, RMSD 1.00 Å
- 3IW4 chain B against the predicted model P17252: TM-score 0.96, RMSD 1.48 Å
- 3IW4 chain B against the predicted model P17252: TM-score 0.96, RMSD 1.48 Å
- 3IW4 chain A against the predicted model P17252: TM-score 0.96, RMSD 1.40 Å
- 3IW4 chain A against the predicted model P17252: TM-score 0.96, RMSD 1.40 Å
- 3IW4 chain C against the predicted model P17252: TM-score 0.95, RMSD 1.69 Å
- 3IW4 chain C against the predicted model P17252: TM-score 0.95, RMSD 1.69 Å
- 2ELI chain A against the predicted model P17252: TM-score 0.65, RMSD 2.49 Å
Elsewhere
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