MolNFT v1 · #35775 · protein

Solution structure of the second phorbol ESTERS/DIACYLGLYCEROL binding domain of human protein kinase C alpha type

2ELI: “Solution structure of the second phorbol ESTERS/DIACYLGLYCEROL binding domain of human protein kinase C alpha…”. Solution nmr, 1 ligand (ZN), 1 pocket (best druggability 0.30). MolNFT v1 #35775 on GenesisL1: 3D structure, binding…

PDB: 2ELI
Type: protein
Length: 85 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein kinase C alpha type
EC: 2.7.11.13
UniProt: P17252
Ligands: ZN
Pockets: 1 · best druggability 0.30

Structure

solution nmr · 1 distinct chain · 0% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein kinase C alpha type (EC 2.7.11.13)	protein	85	0% helix, 13% strand	P17252

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	85	0.30	0.72	17	empty

Compared structures

2ELI · Solution structure of the second Phorbol esters/diacylglycerol binding domain of human… · the same entry in another collection · chain A against A, TM-score 1.00
P17252 · AlphaFold monomer V2.0 prediction for protein kinase C alpha type (P17252) · a predicted model of the same protein · chain A against A, TM-score 0.65

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17252
Elsewhere: RCSB PDB 2ELI · PDBe 2ELI · UniProt P17252

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