MolNFT v1 · #88345 · protein
Complex of human DDX6 (reca-C) and CNOT1 (MIF4G)
4CRW · CCR4-not transcription complex subunit 1: “Complex of human DDX6 (reca-C) and CNOT1 (MIF4G)”. X-ray diffraction, 3 pockets (best druggability 0.49). MolNFT v1 #88345 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4CRW
- Type
- protein
- Length
- 384 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CCR4-not transcription complex subunit 1; Probable ATP-dependent RNA helicase DDX6
- EC
- 3.6.1.-
- UniProt
- A5YKK6, P26196
- Pockets
- 3 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CCR4-not transcription complex subunit 1 | protein | 226 | 72% helix, 0% strand | A5YKK6 |
| B | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) | protein | 158 | 41% helix, 23% strand | P26196 |
Ligands and binding sites
- GOL · Glycerol · additive · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.49 | 0.75 | 30 | empty |
| 2 | 96 | 0.37 | 0.75 | 20 | GOL |
| 3 | 55 | 0.34 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 715 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 4CRW · Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G) · the same entry in another collection · chain A against A, TM-score 1.00
- A5YKK6 · AlphaFold monomer V2.0 prediction for CCR4-not transcription complex subunit 1 (A5YKK6) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P26196 · AlphaFold monomer V2.0 prediction for probable ATP-dependent RNA helicase DDX6 (P26196) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5YKK6
- Every structure of UniProt P26196
- Elsewhere: RCSB PDB 4CRW · PDBe 4CRW · UniProt A5YKK6 · UniProt P26196
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