UniProt A5YKK6
CCR4-NOT transcription complex subunit 1 (A5YKK6)
CCR4-NOT transcription complex subunit 1 (UniProt A5YKK6): 34 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 291 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- A5YKK6
- Protein
- CCR4-NOT transcription complex subunit 1
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 291 · 30 records with a druggable one
Structures
35 records of A5YKK6 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4C0D | Structure of the NOT module of the human CCR4-NOT complex (CNOT1-CNOT2-CNOT3) | x-ray diffraction | A | — | 8 (best 0.80) |
| 4C0D | Structure of the not module of the human CCR4-not complex (CNOT1-CNOT2-CNOT3) | x-ray diffraction | A | — | 8 (best 0.80) |
| 4CQO | Structure of the human CNOT1 superfamily homology domain in complex with a Nanos1 peptide | x-ray diffraction | A, C | — | 14 (best 0.83) |
| 4CQO | Structure of the human CNOT1 superfamily homology domain in complex with a NANOS1 peptide | x-ray diffraction | A, C | — | 14 (best 0.83) |
| 4CRU | Complex of human CNOT9 and CNOT1 including one tryptophan | x-ray diffraction | A | — | 5 (best 0.57) |
| 4CRU | Complex of human CNOT9 and CNOT1 including one tryptophan | x-ray diffraction | A | — | 5 (best 0.57) |
| 4CRV | Complex of human CNOT9 and CNOT1 including two tryptophans | x-ray diffraction | A | — | 3 (best 0.56) |
| 4CRV | Complex of human CNOT9 and CNOT1 including two tryptophans | x-ray diffraction | A | — | 3 (best 0.56) |
| 4CRW | Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G) | x-ray diffraction | A | — | 3 (best 0.49) |
| 4CRW | Complex of human DDX6 (reca-C) and CNOT1 (MIF4G) | x-ray diffraction | A | — | 3 (best 0.49) |
| 4CT4 | CNOT1 MIF4G domain - DDX6 complex | x-ray diffraction | A, C | — | 8 (best 0.78) |
| 4CT4 | CNOT1 MIF4G domain - DDX6 complex | x-ray diffraction | A, C | — | 8 (best 0.78) |
| 4CT6 | CNOT9-CNOT1 complex | x-ray diffraction | A | — | 4 (best 0.59) |
| 4CT6 | CNOT9-CNOT1 complex | x-ray diffraction | A | — | 4 (best 0.59) |
| 4CT7 | CNOT9-CNOT1 complex with bound tryptophan | x-ray diffraction | A | — | 3 (best 0.59) |
| 4CT7 | CNOT9-CNOT1 complex with bound tryptophan | x-ray diffraction | A | — | 3 (best 0.59) |
| 4GMJ | Structure of human NOT1 MIF4G domain co-crystallized with CAF1 | x-ray diffraction | A, C, E | — | 17 (best 0.76) |
| 4GMJ | Structure of human NOT1 MIF4G domain co-crystallized with CAF1 | x-ray diffraction | A, C, E | — | 17 (best 0.76) |
| 4GML | Crystal structure of human NOT1 MIF4G domain | x-ray diffraction | A, B, C, D, E, F | — | 14 (best 0.81) |
| 4GML | Crystal structure of human NOT1 MIF4G domain | x-ray diffraction | A, B, C, D, E, F | — | 14 (best 0.81) |
| 4J8S | Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide | x-ray diffraction | A | — | — |
| 4J8S | Crystal structure of human CNOT1 MIF4G domain in complex with a ttp peptide | x-ray diffraction | A | — | — |
| 5ANR | Structure of a human 4E-T - DDX6 - CNOT1 complex | x-ray diffraction | A | — | 3 (best 0.64) |
| 5ANR | Structure of a human 4E-T - DDX6 - CNOT1 complex | x-ray diffraction | A | — | 3 (best 0.64) |
| 5FU6 | NOT module of the human CCR4-NOT complex (Crystallization mutant) | x-ray diffraction | A, D | — | 19 (best 0.78) |
| 5FU6 | Not module of the human CCR4-not complex (crystallization mutant) | x-ray diffraction | A, D | — | 19 (best 0.78) |
| 5FU7 | drosophila nanos NBR peptide bound to the NOT module of the human CCR4-NOT complex | x-ray diffraction | A, E | — | 17 (best 0.84) |
| 5FU7 | Drosophila nanos nbr peptide bound to the not module of the human CCR4-not complex | x-ray diffraction | A, E | — | 17 (best 0.84) |
| 5ONA | Drosophila Bag-of-marbles CBM peptide bound to human CAF40-CNOT1 | x-ray diffraction | A, D | SO4, CL | 13 (best 0.82) |
| 5ONA | Drosophila bag-of-marbles cbm peptide bound to human CAF40-CNOT1 | x-ray diffraction | A, D | SO4, CL | 13 (best 0.82) |
| 7VOI | Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex | x-ray diffraction | A | — | 4 (best 0.61) |
| 7VOI | Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex | x-ray diffraction | A | — | 4 (best 0.61) |
| 8BFI | human CNOT1-CNOT10-CNOT11 module | x-ray diffraction | A | — | 12 (best 0.85) |
| 8FY3 | Structure of NOT1:NOT10:NOT11 module of the human CCR4-NOT complex | electron microscopy | A | — | 9 (best 0.85) |
| A5YKK6 | AlphaFold monomer V2.0 prediction for CCR4-not transcription complex subunit 1 (A5YKK6) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4GMJ chain C against the predicted model A5YKK6: TM-score 0.99, RMSD 0.75 Å
- 4GMJ chain C against the predicted model A5YKK6: TM-score 0.99, RMSD 0.75 Å
- 4CRW chain A against the predicted model A5YKK6: TM-score 0.98, RMSD 0.83 Å
- 4CRW chain A against the predicted model A5YKK6: TM-score 0.98, RMSD 0.83 Å
- 4C0D chain A against the predicted model A5YKK6: TM-score 0.98, RMSD 1.22 Å
- 4C0D chain A against the predicted model A5YKK6: TM-score 0.98, RMSD 1.22 Å
- 4GML chain C against the predicted model A5YKK6: TM-score 0.98, RMSD 0.88 Å
- 4GML chain C against the predicted model A5YKK6: TM-score 0.98, RMSD 0.88 Å
- 4GML chain E against the predicted model A5YKK6: TM-score 0.98, RMSD 1.06 Å
- 4GML chain E against the predicted model A5YKK6: TM-score 0.98, RMSD 1.06 Å
Elsewhere
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