UniProt P26196
Probable ATP-dependent RNA helicase DDX6 (P26196)
Probable ATP-dependent RNA helicase DDX6 (UniProt P26196), EC 3.6.4.13: 18 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P26196
- Protein
- Probable ATP-dependent RNA helicase DDX6
- EC
- 3.6.4.13
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 11 · 1 record with a druggable one
Structures
19 records of P26196 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1VEC | Crystal structure of the N-terminal domain of rck/p54, a human DEAD-box protein | x-ray diffraction | A, B | — | — |
| 1VEC | Crystal structure of the N-terminal domain of RCK/P54, a human dead- box protein | x-ray diffraction | A, B | — | — |
| 2WAX | Structure of the human DDX6 C-terminal domain in complex with an EDC3- FDF peptide | x-ray diffraction | A, C | — | — |
| 2WAX | Structure of the human DDX6 C-terminal domain in complex with an EDC3-fdf peptide | x-ray diffraction | A, C | — | — |
| 2WAY | Structure of the human DDX6 C-terminal domain in complex with an EDC3- FDF peptide | x-ray diffraction | A, C | — | — |
| 2WAY | Structure of the human DDX6 C-terminal domain in complex with an EDC3-fdf peptide | x-ray diffraction | A, C | — | — |
| 4CRW | Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G) | x-ray diffraction | B | — | — |
| 4CRW | Complex of human DDX6 (reca-C) and CNOT1 (MIF4G) | x-ray diffraction | B | — | — |
| 4CT4 | CNOT1 MIF4G domain - DDX6 complex | x-ray diffraction | B, D | — | — |
| 4CT4 | CNOT1 MIF4G domain - DDX6 complex | x-ray diffraction | B, D | — | — |
| 4CT5 | DDX6 | x-ray diffraction | A, B | — | — |
| 4CT5 | DDX6 | x-ray diffraction | A, B | — | — |
| 5ANR | Structure of a human 4E-T - DDX6 - CNOT1 complex | x-ray diffraction | B | — | — |
| 5ANR | Structure of a human 4E-T - DDX6 - CNOT1 complex | x-ray diffraction | B | — | — |
| 6F9S | Crystal structure of the C-terminal RecA domain of DDX6 in complex with a conserved peptide from… | x-ray diffraction | A | SO4 | 3 (best 0.41) |
| 6F9S | Crystal structure of the C-terminal reca domain of DDX6 in complex with a conserved peptide from… | x-ray diffraction | A | SO4 | — |
| 6S8S | Extended structure of the human DDX6 C-terminal domain in complex with an EDC3 FDF peptide | x-ray diffraction | A, C | PO4 | 8 (best 0.52) |
| 6S8S | Extended structure of the human DDX6 C-terminal domain in complex with an EDC3 fdf peptide | x-ray diffraction | A, C | PO4 | — |
| P26196 | AlphaFold monomer V2.0 prediction for probable ATP-dependent RNA helicase DDX6 (P26196) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2WAY chain A against the predicted model P26196: TM-score 0.98, RMSD 0.67 Å
- 2WAY chain A against the predicted model P26196: TM-score 0.98, RMSD 0.67 Å
- 2WAY chain C against the predicted model P26196: TM-score 0.98, RMSD 0.69 Å
- 2WAY chain C against the predicted model P26196: TM-score 0.98, RMSD 0.69 Å
- 1VEC chain A against the predicted model P26196: TM-score 0.98, RMSD 1.15 Å
- 1VEC chain A against the predicted model P26196: TM-score 0.98, RMSD 1.15 Å
- 1VEC chain B against the predicted model P26196: TM-score 0.97, RMSD 1.16 Å
- 1VEC chain B against the predicted model P26196: TM-score 0.97, RMSD 1.16 Å
- 4CRW chain B against the predicted model P26196: TM-score 0.96, RMSD 1.01 Å
- 4CRW chain B against the predicted model P26196: TM-score 0.96, RMSD 1.01 Å
Elsewhere
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