MolNFT v1 · #86959 · protein
Crystal structure of the N terminal domain of human galectin 8, F19Y mutant
4BME · Galectin-8: “Crystal structure of the N terminal domain of human galectin 8, F19Y mutant”. X-ray diffraction, 2 ligands (GLC, GAL), 2 pockets (best druggability 0.46). MolNFT v1 #86959 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4BME
- Type
- protein
- Length
- 293 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galectin-8
- UniProt
- O00214
- Ligands
- GLC, GAL
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Galectin-8 | protein | 147 | 2% helix, 55% strand | O00214 |
| B | Galectin-8 | protein | 146 | 2% helix, 60% strand | O00214 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A, B
- GAL · beta-D-galactopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.46 | 0.76 | 28 | empty |
| 2 | 81 | 0.34 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 584 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00214
- Elsewhere: RCSB PDB 4BME · PDBe 4BME · UniProt O00214
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