MolNFT v1 · #86590 · protein
Crystal structure of glucokinase regulatory protein complexed to fructose-1-phosphate
4BB9: “Crystal structure of glucokinase regulatory protein complexed to fructose-1-phosphate”. X-ray diffraction, 2 ligands (F1P, CA), 6 pockets (best druggability 0.77). MolNFT v1 #86590 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4BB9
- Type
- protein
- Length
- 596 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucokinase regulatory protein
- UniProt
- Q14397
- Ligands
- F1P, CA
- Pockets
- 6 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucokinase regulatory protein | protein | 596 | 53% helix, 11% strand | Q14397 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 317 | 0.77 | 0.88 | 33 | empty |
| 2 | 68 | 0.72 | 0.98 | 25 | F1P |
| 3 | 190 | 0.54 | 0.79 | 38 | empty |
| 4 | 186 | 0.50 | 0.77 | 36 | empty |
| 5 | 76 | 0.38 | 0.78 | 15 | empty |
Compared structures
- 4BB9 · Crystal structure of glucokinase regulatory protein complexed to fructose-1-phosphate · the same entry in another collection · chain A against A, TM-score 1.00
- Q14397 · AlphaFold monomer V2.0 prediction for glucokinase regulatory protein (Q14397) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14397
- Elsewhere: RCSB PDB 4BB9 · PDBe 4BB9 · UniProt Q14397
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