MolNFT v1 · #85955 · protein
The crystal structure of GTR1P-GTR2P complexed with GTP-GDP
4ARZ · GTP-binding protein GTR1: “The crystal structure of GTR1P-GTR2P complexed with GTP-GDP”. X-ray diffraction, 3 ligands (GTP, GDP, MG), 8 pockets (best druggability 0.71). MolNFT v1 #85955 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4ARZ
- Type
- protein
- Length
- 595 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP-binding protein GTR1; GTP-binding protein GTR2
- UniProt
- Q00582, P53290
- Ligands
- GTP, GDP, MG
- Pockets
- 8 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP-binding protein GTR1 | protein | 291 | 40% helix, 24% strand | Q00582 |
| B | GTP-binding protein GTR2 | protein | 304 | 44% helix, 20% strand | P53290 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A
- GDP · Guanosine-5'-diphosphate · ligand · chains A, B
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 692 | 0.71 | 0.78 | 67 | empty |
| 2 | 53 | 0.57 | 0.90 | 17 | empty |
| 3 | 151 | 0.46 | 0.76 | 22 | empty |
| 4 | 101 | 0.44 | 0.79 | 17 | empty |
| 5 | 115 | 0.43 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1594 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 4ARZ · The crystal structure of Gtr1p-Gtr2p complexed with GTP-GDP · the same entry in another collection · chain A against A, TM-score 1.00
- Q00582 · AlphaFold monomer V2.0 prediction for GTP-binding protein GTR1 (Q00582) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P53290 · AlphaFold monomer V2.0 prediction for GTP-binding protein GTR2 (P53290) · a predicted model of the same protein · chain B against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00582
- Every structure of UniProt P53290
- Elsewhere: RCSB PDB 4ARZ · PDBe 4ARZ · UniProt Q00582 · UniProt P53290
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