MolNFT v1 · #84651 · protein
Structure of galactocerebrosidase from mouse
3ZR5: “Structure of galactocerebrosidase from mouse”. X-ray diffraction, 2 ligands (NAG, CA), 4 pockets (best druggability 0.49). MolNFT v1 #84651 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3ZR5
- Type
- protein
- Length
- 641 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galactocerebrosidase
- EC
- 3.2.1.46
- UniProt
- P54818
- Ligands
- NAG, CA
- Pockets
- 4 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Galactocerebrosidase (EC 3.2.1.46) | protein | 641 | 18% helix, 34% strand | P54818 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.49 | 0.84 | 18 | empty |
| 2 | 56 | 0.43 | 0.82 | 15 | empty |
| 3 | 122 | 0.38 | 0.74 | 21 | empty |
| 4 | 50 | 0.25 | 0.73 | 15 | empty |
Modifications
Observed in the structure: 4 glycan, 1 disulfide (N-glycosylation, disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54818
- Elsewhere: RCSB PDB 3ZR5 · PDBe 3ZR5 · UniProt P54818
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