MolNFT v1 · #84134 · protein
Apaf-1 card in complex with prodomain of procaspase-9
3YGS · Apoptotic protease activating factor 1: “Apaf-1 card in complex with prodomain of procaspase-9”. X-ray diffraction, 1 pocket (best druggability 0.36). MolNFT v1 #84134 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3YGS
- Type
- protein
- Length
- 192 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptotic protease activating factor 1; Procaspase 9
- EC
- 3.4.22.-
- UniProt
- O14727, P55211
- Pockets
- 1 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Apoptotic protease activating factor 1 | protein | 95 | 74% helix, 0% strand | O14727 |
| P | Procaspase 9 (EC 3.4.22.-) | protein | 97 | 66% helix, 0% strand | P55211 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.36 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- C–P · 486 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 3YGS · Apaf-1 card in complex with prodomain of procaspase-9 · the same entry in another collection · chain C against C, TM-score 1.00
- P55211 · AlphaFold monomer V2.0 prediction for caspase-9 (P55211) · a predicted model of the same protein · chain P against A, TM-score 0.96
- O14727 · AlphaFold monomer V2.0 prediction for apoptotic protease-activating factor 1 (O14727) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14727
- Every structure of UniProt P55211
- Elsewhere: RCSB PDB 3YGS · PDBe 3YGS · UniProt O14727 · UniProt P55211
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.