UniProt O14727
Apoptotic protease-activating factor 1 (O14727)
Apoptotic protease-activating factor 1 (UniProt O14727): 25 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14727
- Protein
- Apoptotic protease-activating factor 1
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 24 · 2 records with a druggable one
Structures
26 records of O14727 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C15 | Solution structure of apaf-1 card | solution nmr | A | — | — |
| 1C15 | Solution structure of apaf-1 card | solution nmr | A | — | — |
| 1CWW | Solution structure of the caspase recruitment domain (card) from apaf-1 | solution nmr | A | — | — |
| 1CWW | Solution structure of the caspase recruitment domain (card) from apaf- 1 | solution nmr | A | — | — |
| 1CY5 | Crystal structure of the apaf-1 card | x-ray diffraction | A | — | — |
| 1CY5 | Crystal structure of the apaf-1 card | x-ray diffraction | A | — | — |
| 1Z6T | Structure of the apoptotic protease-activating factor 1 bound to ADP | x-ray diffraction | A, B, C, D | — | — |
| 1Z6T | Structure of the apoptotic protease-activating factor 1 bound to ADP | x-ray diffraction | A, B, C, D | — | — |
| 2P1H | Rapid Folding and Unfolding of Apaf-1 CARD | x-ray diffraction | A | — | — |
| 2P1H | Rapid folding and unfolding of apaf-1 card | x-ray diffraction | A | — | — |
| 2YGS | Card domain from apaf-1 | x-ray diffraction | A | — | — |
| 2YGS | Card domain from apaf-1 | x-ray diffraction | A | — | — |
| 3J2T | An improved model of the human apoptosome | electron microscopy | A, B, C, D, E, F, G | — | — |
| 3J2T | An improved model of the human apoptosome | electron microscopy | A, B, C, D, E, F, G | — | — |
| 3JBT | Atomic structure of the Apaf-1 apoptosome | electron microscopy | A, C, E, G, I, K, M | — | — |
| 3JBT | Atomic structure of the apaf-1 apoptosome | electron microscopy | A, C, E, G, I, K, M | — | — |
| 3YGS | Apaf-1 card in complex with prodomain of procaspase-9 | x-ray diffraction | C | — | — |
| 3YGS | Apaf-1 card in complex with prodomain of procaspase-9 | x-ray diffraction | C | — | — |
| 4RHW | Crystal structure of Apaf-1 CARD and caspase-9 CARD complex | x-ray diffraction | A, B, C, D | — | — |
| 4RHW | Crystal structure of apaf-1 card and caspase-9 card complex | x-ray diffraction | A, B, C, D | — | — |
| 5JUY | Active human apoptosome with procaspase-9 | electron microscopy | A, B, C, D, E, F, G | DTP | 20 (best 0.87) |
| 5JUY | Active human apoptosome with procaspase-9 | electron microscopy | A, B, C, D, E, F, G | — | — |
| 5WVC | Structure of the card-card disk | x-ray diffraction | C, A, E | IOD | — |
| 5WVE | Apaf-1-caspase-9 holoenzyme | electron microscopy | A, C, E, G, I, K, M, O, P, Q, R, W, X | DTP, MG | — |
| 8XQK | The Crystal Structure of Apaf from Biortus. | x-ray diffraction | A, B, C, D | PO4 | 4 (best 0.52) |
| O14727 | AlphaFold monomer V2.0 prediction for apoptotic protease-activating factor 1 (O14727) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4RHW chain D against the predicted model O14727: TM-score 0.98, RMSD 0.46 Å
- 4RHW chain D against the predicted model O14727: TM-score 0.98, RMSD 0.46 Å
- 4RHW chain B against the predicted model O14727: TM-score 0.98, RMSD 0.46 Å
- 4RHW chain B against the predicted model O14727: TM-score 0.98, RMSD 0.46 Å
- 5WVE chain X against the predicted model O14727: TM-score 0.98, RMSD 0.46 Å
- 5WVE chain R against the predicted model O14727: TM-score 0.98, RMSD 0.48 Å
- 5WVE chain O against the predicted model O14727: TM-score 0.98, RMSD 0.48 Å
- 5WVE chain P against the predicted model O14727: TM-score 0.98, RMSD 0.48 Å
- 2YGS chain A against the predicted model O14727: TM-score 0.98, RMSD 0.49 Å
- 2YGS chain A against the predicted model O14727: TM-score 0.98, RMSD 0.49 Å
Elsewhere
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