MolNFT v1 · #83935 · protein
Yeast 20S proteasome with a mutation of ALPHA7 subunit
3WXR · Proteasome subunit alpha type-1: “Yeast 20S proteasome with a mutation of ALPHA7 subunit”. X-ray diffraction, 20 pockets (best druggability 0.83). MolNFT v1 #83935 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3WXR
- Type
- protein
- Length
- 6,343 residues
- Chains
- 28
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha type-1; Proteasome subunit alpha type-2; Proteasome subunit…
- EC
- 3.4.25.1
- UniProt
- P21243, P23639, P23638, P40303, P32379, P40302, P21242, P38624, P25043, P25451, P22141, P30656, P23724, P30657
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 18 distinct chains · 35% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, O | Proteasome subunit alpha type-1 (EC 3.4.25.1) | protein | 243 | 40% helix, 23% strand | P21243 |
| B, P | Proteasome subunit alpha type-2 (EC 3.4.25.1) | protein | 249 | 37% helix, 26% strand | P23639 |
| C | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 242 | 36% helix, 24% strand | P23638 |
| D, R | Proteasome subunit alpha type-4 (EC 3.4.25.1) | protein | 241 | 38% helix, 24% strand | P40303 |
| E | Proteasome subunit alpha type-5 (EC 3.4.25.1) | protein | 239 | 37% helix, 26% strand | P32379 |
| F, T | Proteasome subunit alpha type-6 (EC 3.4.25.1) | protein | 232 | 34% helix, 28% strand | P40302 |
| G, U | Probable proteasome subunit alpha type-7 (EC 3.4.25.1) | protein | 237 | 38% helix, 27% strand | P21242 |
| H | Proteasome subunit beta type-1 (EC 3.4.25.1) | protein | 196 | 37% helix, 34% strand | P38624 |
| I, W | Proteasome subunit beta type-2 (EC 3.4.25.1) | protein | 222 | 29% helix, 35% strand | P25043 |
| J, X | Proteasome subunit beta type-3 (EC 3.4.25.1) | protein | 204 | 31% helix, 33% strand | P25451 |
| K | Proteasome subunit beta type-4 (EC 3.4.25.1) | protein | 197 | 35% helix, 34% strand | P22141 |
| L, Z | Proteasome subunit beta type-5 (EC 3.4.25.1) | protein | 212 | 36% helix, 34% strand | P30656 |
| M, 1 | Proteasome subunit beta type-6 (EC 3.4.25.1) | protein | 222 | 29% helix, 33% strand | P23724 |
| N, 2 | Proteasome subunit beta type-7 (EC 3.4.25.1) | protein | 233 | 31% helix, 31% strand | P30657 |
| Q | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 244 | 37% helix, 25% strand | P23638 |
| S | Proteasome subunit alpha type-5 (EC 3.4.25.1) | protein | 238 | 37% helix, 26% strand | P32379 |
| V | Proteasome subunit beta type-1 (EC 3.4.25.1) | protein | 199 | 36% helix, 32% strand | P38624 |
| Y | Proteasome subunit beta type-4 (EC 3.4.25.1) | protein | 198 | 33% helix, 34% strand | P22141 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 988 | 0.83 | 0.84 | 140 | empty |
| 2 | 911 | 0.81 | 0.83 | 117 | empty |
| 3 | 811 | 0.81 | 0.83 | 102 | empty |
| 4 | 754 | 0.80 | 0.84 | 111 | empty |
| 5 | 1116 | 0.79 | 0.81 | 117 | empty |
Interfaces
92 interfaces between chains.
- W–X · 1693 Ų buried · 31 hydrogen bonds · protein-protein
- I–J · 1656 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 1611 Ų buried · 24 hydrogen bonds · protein-protein
- Q–R · 1573 Ų buried · 22 hydrogen bonds · protein-protein
- M–W · 1458 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 3WXR · Yeast 20S proteasome with a mutation of alpha7 subunit · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21243
- Every structure of UniProt P23639
- Every structure of UniProt P23638
- Every structure of UniProt P40303
- Every structure of UniProt P32379
- Every structure of UniProt P40302
- Every structure of UniProt P21242
- Every structure of UniProt P38624
- Every structure of UniProt P25043
- Every structure of UniProt P25451
- Every structure of UniProt P22141
- Every structure of UniProt P30656
- Every structure of UniProt P23724
- Every structure of UniProt P30657
- Elsewhere: RCSB PDB 3WXR · PDBe 3WXR · UniProt P21243 · UniProt P23639 · UniProt P23638 · UniProt P40303 · UniProt P32379 · UniProt P40302 · UniProt P21242 · UniProt P38624 · UniProt P25043 · UniProt P25451 · UniProt P22141 · UniProt P30656 · UniProt P23724 · UniProt P30657
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.