MolNFT v1 · #83808 · protein + DNA
Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, cbfbeta, and the tcralpha gene enhancer DNA
3WTX · Runt-related transcription factor 1: “Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, cbfbeta, and the tcralpha gene enhancer DNA”. X-ray diffraction, 14 pockets (best druggability 0.62). MolNFT v1 #83808 on…
- PDB
- 3WTX
- Type
- protein + DNA
- Length
- 761 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Runt-related transcription factor 1; Core-binding factor subunit beta; Protein C-ets-1…
- UniProt
- Q03347, Q08024, P14921
- Pockets
- 14 · best druggability 0.62
Structure
x-ray diffraction · 7 distinct chains · 27% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, F | Runt-related transcription factor 1 | protein | 118 | 0% helix, 36% strand | Q03347 |
| B | Core-binding factor subunit beta | protein | 132 | 26% helix, 33% strand | Q08024 |
| C | Protein C-ets-1 | protein | 103 | 50% helix, 12% strand | P14921 |
| G | Core-binding factor subunit beta | protein | 130 | 27% helix, 34% strand | Q08024 |
| H | Protein C-ets-1 | protein | 100 | 37% helix, 7% strand | P14921 |
| D, I | DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)- 3') | dna | 15 | — | — |
| E, J | DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)- 3') | dna | 15 | — | — |
Pockets
14 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.62 | 0.77 | 30 | empty |
| 2 | 345 | 0.60 | 0.78 | 28 | empty |
| 3 | 149 | 0.49 | 0.79 | 19 | empty |
| 4 | 204 | 0.49 | 0.76 | 29 | empty |
| 5 | 127 | 0.49 | 0.80 | 15 | empty |
Interfaces
19 interfaces between chains.
- A–B · 1212 Ų buried · 20 hydrogen bonds · protein-protein
- F–G · 1128 Ų buried · 20 hydrogen bonds · protein-protein
- I–J · 663 Ų buried · 56 hydrogen bonds · nucleic-nucleic
- D–E · 657 Ų buried · 45 hydrogen bonds · nucleic-nucleic
- H–I · 517 Ų buried · 10 hydrogen bonds · protein-nucleic
Compared structures
- 3WTX · Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, CBFBETA, and the… · the same entry in another collection · chain J against J, TM-score 1.00
- Q08024 · AlphaFold monomer V2.0 prediction for core-binding factor subunit beta (Q08024) · a predicted model of the same protein · chain G against A, TM-score 0.98
- Q03347 · AlphaFold monomer V2.0 prediction for runt-related transcription factor 1 (Q03347) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03347
- Every structure of UniProt Q08024
- Every structure of UniProt P14921
- Elsewhere: RCSB PDB 3WTX · PDBe 3WTX · UniProt Q03347 · UniProt Q08024 · UniProt P14921
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