MolNFT v1 · #82703 · protein
Crystal structure of histone methyltransferase SET7/9 in complex with daam-3
3VV0 · Histone-lysine N-methyltransferase SETD7: “Crystal structure of histone methyltransferase SET7/9 in complex with daam-3”. X-ray diffraction, 1 ligand (KH3), 1 pocket (best druggability 0.52). MolNFT v1 #82703 on GenesisL1: 3D…
- PDB
- 3VV0
- Type
- protein
- Length
- 235 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-lysine N-methyltransferase SETD7
- EC
- 2.1.1.43
- UniProt
- Q8WTS6
- Ligands
- KH3
- Pockets
- 1 · best druggability 0.52
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.43) | protein | 235 | 11% helix, 40% strand | Q8WTS6 |
Ligands and binding sites
- KH3 · 5'-{[(3S)-3-amino-3-carboxypropyl][2-(hexylamino)ethyl]amino}-5'-deoxyadenosine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.52 | 0.76 | 32 | KH3 |
Compared structures
- 3VV0 · Crystal structure of histone methyltransferase SET7/9 in complex with DAAM-3 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WTS6 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD7 (Q8WTS6) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WTS6
- Elsewhere: RCSB PDB 3VV0 · PDBe 3VV0 · UniProt Q8WTS6
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