MolNFT v1 · #82132 · protein
Crystal structure of human AIM2 pyd domain with mbp fusion
3VD8 · Maltose-binding periplasmic protein, interferon-inducible…: “Crystal structure of human AIM2 pyd domain with mbp fusion”. X-ray diffraction, 2 ligands (GLC, K), 4 pockets (best druggability 0.71). MolNFT v1 #82132 on GenesisL1: 3D…
- PDB
- 3VD8
- Type
- protein
- Length
- 467 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic protein, interferon-inducible protein AIM2
- UniProt
- P0AEY0, O14862
- Ligands
- GLC, K
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic protein, interferon-inducible protein AIM2 | protein | 467 | 50% helix, 16% strand | P0AEY0, O14862 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A
- K · Potassium ion · metal · 4 copies · chains A
- EDO · 1,2-ethanediol · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 385 | 0.71 | 0.83 | 33 | GLC |
| 2 | 223 | 0.48 | 0.74 | 36 | K |
| 3 | 108 | 0.45 | 0.79 | 16 | empty |
| 4 | 60 | 0.40 | 0.80 | 16 | empty |
Compared structures
- 3VD8 · Crystal structure of human AIM2 PYD domain with MBP fusion · the same entry in another collection · chain A against A, TM-score 1.00
- O14862 · AlphaFold monomer V2.0 prediction for interferon-inducible protein AIM2 (O14862) · a predicted model of the same protein · chain A against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEY0
- Every structure of UniProt O14862
- Elsewhere: RCSB PDB 3VD8 · PDBe 3VD8 · UniProt P0AEY0 · UniProt O14862
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.