UniProt O14862
Interferon-inducible protein AIM2 (O14862)
Interferon-inducible protein AIM2 (UniProt O14862): 12 experimental structures and 1 predicted model on GenesisL1, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14862
- Protein
- Interferon-inducible protein AIM2
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 25 · 2 records with a druggable one
Structures
13 records of O14862 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3RN2 | Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors | x-ray diffraction | A, B | — | — |
| 3RN2 | Structural basis of cytosolic DNA recognition by innate immune receptors | x-ray diffraction | A, B | — | — |
| 3RN5 | Structural basis of cytosolic DNA recognition by innate immune receptors | x-ray diffraction | A, B, C, D | — | — |
| 3RN5 | Structural basis of cytosolic DNA recognition by innate immune receptors | x-ray diffraction | A, B, C, D | — | — |
| 3VD8 | Crystal structure of human AIM2 PYD domain with MBP fusion | x-ray diffraction | A | — | — |
| 3VD8 | Crystal structure of human AIM2 pyd domain with mbp fusion | x-ray diffraction | A | — | — |
| 4O7Q | Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to… | x-ray diffraction | A | — | — |
| 4O7Q | Crystal structure of the F27G AIM2 pyrin domain mutant and similarities of its self-association to… | x-ray diffraction | A | — | — |
| 6MB2 | Cryo-EM structure of the PYD filament of AIM2 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | 9 (best 0.84) |
| 6MB2 | Cryo-EM structure of the pyd filament of AIM2 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 7K3R | Cryo-EM structure of AIM2-PYD filament | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U | — | 16 (best 0.86) |
| 7K3R | Cryo-EM structure of AIM2-pyd filament | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U | — | — |
| O14862 | AlphaFold monomer V2.0 prediction for interferon-inducible protein AIM2 (O14862) | predicted | A | — | — |
Experiment against prediction
- 3RN2 chain A against the predicted model O14862: TM-score 0.99, RMSD 0.51 Å
- 3RN2 chain A against the predicted model O14862: TM-score 0.99, RMSD 0.51 Å
- 3RN2 chain B against the predicted model O14862: TM-score 0.99, RMSD 0.58 Å
- 3RN2 chain B against the predicted model O14862: TM-score 0.99, RMSD 0.58 Å
- 3RN5 chain C against the predicted model O14862: TM-score 0.99, RMSD 0.64 Å
- 3RN5 chain C against the predicted model O14862: TM-score 0.99, RMSD 0.64 Å
- 3RN5 chain A against the predicted model O14862: TM-score 0.98, RMSD 0.65 Å
- 3RN5 chain A against the predicted model O14862: TM-score 0.98, RMSD 0.65 Å
- 3RN5 chain D against the predicted model O14862: TM-score 0.98, RMSD 0.66 Å
- 3RN5 chain D against the predicted model O14862: TM-score 0.98, RMSD 0.66 Å
Elsewhere
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