MolNFT v1 · #81770 · protein

Vegfr-2/VEGF-a complex structure

3V2A · Vascular endothelial growth factor receptor 2: “Vegfr-2/VEGF-a complex structure”. X-ray diffraction, 3 pockets (best druggability 0.34). MolNFT v1 #81770 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3V2A
Type: protein
Length: 280 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Vascular endothelial growth factor receptor 2; Vascular endothelial growth factor a
EC: 2.7.10.1
UniProt: P35968, P15692
Pockets: 3 · best druggability 0.34

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 58% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R	Vascular endothelial growth factor receptor 2 (EC 2.7.10.1)	protein	185	2% helix, 56% strand	P35968
A	Vascular endothelial growth factor a	protein	95	11% helix, 62% strand	P15692

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.34	0.75	19	empty
2	58	0.30	0.75	16	empty
3	54	0.27	0.73	13	empty

Interfaces

1 interface between chains.

R–A · 698 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

3V2A · Vegfr-2/VEGF-a complex structure · the same entry in another collection · chain R against R, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35968
Every structure of UniProt P15692
Elsewhere: RCSB PDB 3V2A · PDBe 3V2A · UniProt P35968 · UniProt P15692

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