UniProt P15692
Vascular endothelial growth factor A (P15692)
Vascular endothelial growth factor A (UniProt P15692): 81 experimental structures on GenesisL1, 3 ligands bound, 2 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P15692
- Protein
- Vascular endothelial growth factor A
- Experimental structures
- 81
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 2 · 0 records with a druggable one
Structures
81 records of P15692 in the MolNFT archive: 81 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BJ1 | Vascular endothelial growth factor in complex with a neutralizing antibody | x-ray diffraction | V, W | — | — |
| 1BJ1 | Vascular endothelial growth factor in complex with a neutralizing antibody | x-ray diffraction | V, W | — | — |
| 1CZ8 | Vascular endothelial growth factor in complex with an affinity matured antibody | x-ray diffraction | V, W | — | — |
| 1CZ8 | Vascular endothelial growth factor in complex with an affinity matured antibody | x-ray diffraction | V, W | — | — |
| 1FLT | VEGF in complex with domain 2 of the flt-1 receptor | x-ray diffraction | V, W | — | — |
| 1FLT | VEGF in complex with domain 2 of the flt-1 receptor | x-ray diffraction | V, W | — | — |
| 1KAT | Solution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial… | solution nmr | V, W | — | — |
| 1KAT | Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial… | solution nmr | V, W | — | — |
| 1KMX | Heparin-binding Domain from Vascular Endothelial Growth Factor | solution nmr | A | — | — |
| 1KMX | Heparin-binding domain from vascular endothelial growth factor | solution nmr | A | — | — |
| 1MJV | DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C51A and C60A) | x-ray diffraction | A, B | — | — |
| 1MJV | Disulfide deficient mutant of vascular endothelial growth factor a (C51A and C60A) | x-ray diffraction | A, B | — | — |
| 1MKG | DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C57A and C102A) | x-ray diffraction | A, B, C, D | — | — |
| 1MKG | Disulfide deficient mutant of vascular endothelial growth factor a (C57A and C102A) | x-ray diffraction | A, B, C, D | — | — |
| 1MKK | Disulfide deficient mutant of vascular endothelial growth factor A (C61A and C104A) | x-ray diffraction | A, B | — | — |
| 1MKK | Disulfide deficient mutant of vascular endothelial growth factor a (C61A and C104A) | x-ray diffraction | A, B | — | — |
| 1QTY | Vascular endothelial growth factor in complex with domain 2 of the flt-1 receptor | x-ray diffraction | V, W, R, S | — | — |
| 1QTY | Vascular endothelial growth factor in complex with domain 2 of the flt-1 receptor | x-ray diffraction | V, W, R, S | — | — |
| 1TZH | Crystal Structure of the Fab YADS1 Complexed with h-VEGF | x-ray diffraction | V, W | — | — |
| 1TZH | Crystal structure of the Fab YADS1 complexed with H-VEGF | x-ray diffraction | V, W | — | — |
| 1TZI | Crystal Structure of the Fab YADS2 Complexed with h-VEGF | x-ray diffraction | V | — | — |
| 1TZI | Crystal structure of the Fab YADS2 complexed with H-VEGF | x-ray diffraction | V | — | — |
| 1VGH | Heparin-binding domain from vascular endothelial growth factor, NMR, 20 structures | solution nmr | A | — | — |
| 1VGH | Heparin-binding domain from vascular endothelial growth factor, NMR, 20 structures | solution nmr | A | — | — |
| 1VPF | Structure of human vascular endothelial growth factor | x-ray diffraction | A, B, C, D | — | — |
| 1VPF | Structure of human vascular endothelial growth factor | x-ray diffraction | A, B, C, D | — | — |
| 1VPP | Complex between VEGF and a receptor blocking peptide | x-ray diffraction | V, W | — | — |
| 1VPP | Complex between VEGF and a receptor blocking peptide | x-ray diffraction | V, W | — | — |
| 2QR0 | Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs | x-ray diffraction | C, D, I, J, O, P, U, V | — | — |
| 2QR0 | Structure of VEGF complexed to a Fab containing tyr and ser in the cdrs | x-ray diffraction | C, D, I, J, O, P, U, V | — | — |
| 2VGH | Heparin-binding domain from vascular endothelial growth factor, NMR, minimized average structure | solution nmr | A | — | — |
| 2VGH | Heparin-binding domain from vascular endothelial growth factor, NMR, minimized average structure | solution nmr | A | — | — |
| 2VPF | Vascular endothelial growth factor refined to 1.93 ångströms resolution | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2VPF | Vascular endothelial growth factor refined to 1.93 ångströms resolution | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3BDY | Dual specific bH1 Fab in complex with VEGF | x-ray diffraction | V | — | — |
| 3BDY | Dual specific BH1 Fab in complex with VEGF | x-ray diffraction | V | — | — |
| 3P9W | Crystal structure of an engineered human autonomous VH Domain in complex with VEGF | x-ray diffraction | A, C, E, G | — | — |
| 3P9W | Crystal structure of an engineered human autonomous vh domain in complex with VEGF | x-ray diffraction | A, C, E, G | — | — |
| 3QTK | The crystal structure of chemically synthesized VEGF-A | x-ray diffraction | A, D, B, C, E, F | — | — |
| 3QTK | The crystal structure of chemically synthesized VEGF-a | x-ray diffraction | A, D, B, C, E, F | — | — |
| 3S1B | The Development of Peptide-based Tools for the Analysis of Angiogenesis | x-ray diffraction | V | — | — |
| 3S1B | The development of peptide-based tools for the analysis of angiogenesis | x-ray diffraction | V | — | — |
| 3S1K | The Development of Peptide-based Tools for the Analysis of Angiogenesis | x-ray diffraction | V, W | — | — |
| 3S1K | The development of peptide-based tools for the analysis of angiogenesis | x-ray diffraction | V, W | — | — |
| 3V2A | Vegfr-2/VEGF-a complex structure | x-ray diffraction | A | — | — |
| 3V2A | Vegfr-2/VEGF-a complex structure | x-ray diffraction | A | — | — |
| 4DEQ | Structure of the Neuropilin-1/VEGF-A complex | x-ray diffraction | A, B | — | — |
| 4DEQ | Structure of the neuropilin-1/VEGF-a complex | x-ray diffraction | A, B | — | — |
| 4GLN | Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein… | x-ray diffraction | E, F | — | — |
| 4GLN | Crystal structure of chemically synthesized heterochiral {D-protein antagonist plus VEGF-a} protein… | x-ray diffraction | E, F | — | — |
| 4GLS | Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein… | x-ray diffraction | E, F | — | — |
| 4GLS | Crystal structure of chemically synthesized heterochiral {D-protein antagonist plus VEGF-a} protein… | x-ray diffraction | E, F | — | — |
| 4KZN | crystal structure of human VEGF-A receptor binding domain | x-ray diffraction | A | — | — |
| 4KZN | Crystal structure of human VEGF-a receptor binding domain | x-ray diffraction | A | — | — |
| 4QAF | Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109) | x-ray diffraction | C, D | — | — |
| 4QAF | Crystal structure of an engineered lipocalin (anticalin) in complex with VEGF(8-109) | x-ray diffraction | C, D | — | — |
| 4WPB | Vascular endothelial growth factor in complex with alpha/beta-VEGF-1 | x-ray diffraction | A, B | — | — |
| 4WPB | Vascular endothelial growth factor in complex with ALPHA/BETA-VEGF-1 | x-ray diffraction | A, B | — | — |
| 4ZFF | Dual-acting Fab 5A12 in complex with VEGF | x-ray diffraction | C, D | — | — |
| 5DN2 | Human NRP2 b1 domain in complex with the peptide corresponding to the C-terminus of VEGF-A | x-ray diffraction | F, G, E | — | — |
21 records more on the page itself.
Ligands
Experiment against prediction
- 4DEQ chain B against the predicted model O14786: TM-score 0.77, RMSD 3.00 Å
- 4DEQ chain B against the predicted model O14786: TM-score 0.77, RMSD 3.00 Å
- 4DEQ chain A against the predicted model O14786: TM-score 0.76, RMSD 2.54 Å
- 4DEQ chain A against the predicted model O14786: TM-score 0.76, RMSD 2.54 Å
Elsewhere
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